HOME
PRODUCTS
COMPANY
CONTACT
FAQ
Research
Dictionary
Pharma
Sign Up
FREE
or
Login
Username:
Password:
Remember login
Login
Send password reminder...
GAWK
isolated from human pituitary glands; contains 74 amino acids; identical to sequence 420-493 of human chromagranin B
Also Known As:
GAWK-LI; GAWK-like immunoreactivity; chromogranin B (420-493)
Networked:
6
relevant articles (
0
outcomes,
2
trials/studies)
Bio-Agent Context: Research Results
Amino Acids, Peptides, and Proteins: 1
Proteins: 484843
Nerve Tissue Proteins: 2
Chromogranins: 1100
Chromogranin B: 107
GAWK: 6
Related Diseases
1.
Neoplasms (Cancer)
06/01/1989 - "
On the other hand, low concentrations of GAWK-LI were found in nonendocrine tumors.
"
06/01/1989 - "
Production of GAWK (chromogranin-B 420-493)-like immunoreactivity by endocrine tumors and its possible diagnostic value.
"
11/01/1993 - "
In the present study, we measured plasma PST- and GAWK-like immunoreactivity (LI) concentrations in 12 patients with pancreatic islet cell tumors and evaluated them as a marker for these tumors.
"
06/01/1989 - "
Chromatographic profiles of GAWK-LI in extracts of pheochromocytomas and normal adrenals showed high molecular weight peaks that were absent in the extracts of other endocrine tumors and normal pancreas, suggesting differential tissue-specific processing.
"
06/01/1989 - "
Plasma concentrations of GAWK-LI were found to be elevated in patients with endocrine tumor, but more so in those with pancreatic tumors than with pheochromocytomas.
"
2.
Thyroid Neoplasms (Thyroid Cancer)
08/01/1990 - "
In the present studies, we investigated effects of phorbol ester (TPA), forskolin and Ca(2+)-ionophore (A23187) on GAWK secretion using a human medullary thyroid carcinoma-derived cell line (TT-cell).
"
08/01/1990 - "
Secretion of GAWK, a Presumed Product of Chromogranin B Processing, by a Human Medullary Thyroid Carcinoma Cell Line: Effect of Phorbol Ester, Forskolin and Calcium-lonophore.
"
3.
Islet Cell Adenoma (Islet Cell Tumors)
11/01/1993 - "
In the present study, we measured plasma PST- and GAWK-like immunoreactivity (LI) concentrations in 12 patients with pancreatic islet cell tumors and evaluated them as a marker for these tumors.
"
11/01/1993 - "
Comparison of plasma pancreastatin and GAWK concentrations, presumed processing products of chromogranin A and B, in plasma of patients with pancreatic islet cell tumors.
"
4.
Carcinoid Tumor (Carcinoid)
06/01/1989 - "
High concentrations of GAWK-LI were also found in other types of endocrine tumors including carcinoid, medullary carcinoma of thyroid, pancreatic, and ACTH-producing lung tumors.
"
10/01/1991 - "
Tissue concentration of 7B2, secretogranin 1 fragments (GAWK and CCB), gastrin releasing peptide and beta-endorphin were measured in normal human lung (n = 4), bronchial carcinoid tumours with (n = 5) and without (n = 15) the ectopic ACTH syndrome, small cell carcinomas (n = 2), squamous cell carcinomas (n = 11) and adenocarcinomas (n = 6).
"
5.
Small Cell Lung Carcinoma (Small Cell Lung Cancer)
01/01/1992 - "
PST-like immunoreactivity (LI) was detected in the culture medium in 3 of 6 small cell lung carcinoma (SCLC) cell lines, while GAWK- and CCB-LIs were detected in 5 of 6 and all the 6 SCLC cell lines, respectively.
"
Related Drugs and Biologics
1.
Phorbol Esters
2.
Ionophores
3.
Colforsin
4.
Calcimycin (A23187)
5.
Gastrin-Releasing Peptide
6.
Peptides (Polypeptides)
7.
Chromogranins
8.
Calcium
9.
pancreastatin
10.
GAWK