|1.||Qi, Zhifeng: 2 articles (10/2015 - 04/2014)|
|2.||Ji, Xunming: 2 articles (10/2015 - 04/2014)|
|3.||Liu, Ke Jian: 2 articles (10/2015 - 04/2014)|
|4.||Zhao, Yongmei: 2 articles (10/2015 - 04/2014)|
|5.||Luo, Yumin: 2 articles (10/2015 - 04/2014)|
|6.||Liu, Zhao: 2 articles (09/2015 - 07/2015)|
|7.||Heng, Bin: 2 articles (09/2015 - 07/2015)|
|8.||Zhang, Chi: 2 articles (05/2014 - 01/2012)|
|9.||Cai, Lu: 2 articles (05/2014 - 01/2012)|
|10.||Li, Bing: 2 articles (05/2014 - 01/2012)|
01/01/1991 - "Likewise, TPEN a heavy metal chelator, provides almost total (greater than 90%) protection against ischemia/reperfusion-induced arrhythmias. "
03/01/2013 - "Using a high-affinity Zn(2+) probe, we showed that ischemia induced an intracellular Zn(2+) rise in oligodendrocytes, and that incubation with TPEN prevented mitochondrial depolarization and ROS generation after ischemia. "
09/01/1992 - "TPEN, a transition metal chelator, improves myocardial protection during prolonged ischemia."
09/01/2015 - "We aim to determine the significant effect of TPEN, a Zn(2+) chelator, in mediating the pathophysiological cascade in neuron death/apoptosis induced by hypoxia/ischemia. "
10/01/2015 - "Finally, ischemia-induced cytochrome c release from mitochondria in penumbral tissues was significantly reduced by NBO or TPEN treatment. "
01/01/2014 - "Here we study the anti-tumor activity of the metal chelator, TPEN, and define its mechanism of action. "
02/01/1994 - "Rather, the action of TPEN is more selective and probably involves chelation of Zn2+ at a critical Zn(2+)-dependent phosphorylation step downstream from the initial tumor promoter-induced effects on PKC."
08/01/1998 - "To characterize StAR expression during apoptosis, mouse MA-10 Leydig tumor cells were treated with ethane dimethane sulfonate (EDS), an inducer of apoptosis, and the metal ion chelator NNN'N'-tetrakis-(2-pyridylmethyl)ethylenediamine (TPEN), an inducer of cell death. "
01/01/2014 - "Consistently, TPEN exhibits robust anti-tumor activity in vivo in colon cancer mouse xenografts. "
01/01/2014 - "Using this approach, we describe thiolutin, CD437 and TPEN as the most potentially valuable drug candidates for addressing drug-resistance caused by aberrant expression of Bcl-2 family proteins in tumor cells. "
|3.||Wounds and Injuries (Trauma)
01/01/2012 - "Zn deficiency exacerbated hepatic injuries, shown by further increased serum ALT, hepatic lipid accumulation, inflammation, oxidative damage, and endoplasmic reticulum stress-related cell death in Diabetes/TPEN group compared to Diabetes alone. "
01/01/2005 - "The aim of the study was to determine whether TPEN, a potent iron chelator, ameliorates the apoptotic hepatic and cardiac function injuries. "
01/01/2015 - "TPEN also prevents muscle necrosis and accumulation of inflammatory cells at the site of ECV injections. "
07/01/2001 - "Exposure of SPAECs to TPEN (10 microM) resulted in enhanced apoptosis after lipopolysaccharide or complete inhibition of t-butyl hydroperoxide (tBH)-induced necrosis. "
08/01/1999 - "Loss of cell viability reached 12% at 8 hr, 61% at 24 hr and 83% by 48 hr. Ultrastructural examination of TPEN-treated cells revealed condensed chromatin and fragmented nuclei, characteristic of apoptosis, as well as plasma membrane defects and organelle swelling, generally associated with necrosis. "
02/01/2012 - "Zinc pyrithione induces ERK- and PKC-dependent necrosis distinct from TPEN-induced apoptosis in prostate cancer cells."
02/01/1999 - "In conclusion, the current data demonstrate that TPEN, most likely by zinc chelation, exerts protective effects against peroxynitrite-induced necrosis. "
04/01/1995 - "Treatment of muscles with a Zn(2+)-TPEN coordination complex, rather than TPEN alone, eliminated any beneficial effects of TPEN on BoNT intoxication, indicating that these effects were mediated by chelation of Zn2+. Other metal chelators that were not as membrane permeant as TPEN were ineffective in delaying BoNT paralysis, suggesting that TPEN acts by chelating intraterminal Zn2+. In the absence of BoNT, TPEN caused a dose-dependent increase in nerve-elicited twitch tension with a half-maximal concentration at 8 microM. "
|4.||Peroxynitrous Acid (Peroxynitrite)
|1.||Enteral Nutrition (Feeding, Tube)
|3.||Gamma Cameras (Gamma Camera)
|4.||Heterologous Transplantation (Xenotransplantation)
|5.||Drug Therapy (Chemotherapy)