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N-glycolylneuraminyllactosylceramide (HD3)

influenza A virus receptor which mediates the adsorption-fusion process of viral infection
Also Known As:
HD3; GM3-NeuGc; N-glycoloyl-GM3; N-glycolyl-neuraminyl-lactosyl-ceramide; NeuGc(alpha2-3)Gal(beta1-4)Glc(beta1-1)Cer; NeuGc-GM3; Ganglioside GM3, N-deacetyl-N-(hydroxyacetyl)-, (5alpha,17alpha)-
Networked: 36 relevant articles (0 outcomes, 6 trials/studies)

Bio-Agent Context: Research Results

Experts

1. Camarero, Sandra: 3 articles (06/2015 - 01/2010)
2. de Dávila, María Teresa G: 3 articles (06/2015 - 01/2010)
3. Li, Caixia: 2 articles (01/2021 - 09/2020)
4. Lin, Chunlong: 2 articles (01/2021 - 09/2020)
5. Ni, Wang: 2 articles (01/2021 - 09/2020)
6. Yi, Jizu: 2 articles (01/2021 - 09/2020)
7. Zhao, Jianping: 2 articles (01/2021 - 09/2020)
8. Chantada, Guillermo: 2 articles (06/2015 - 01/2011)
9. Hayward, Janis: 2 articles (05/2014 - 01/2012)
10. Hewitt, Martin: 2 articles (05/2014 - 01/2012)

Related Diseases

1. Neoplasms (Cancer)
2. Hodgkin Disease (Hodgkin's Disease)
3. Carcinoma (Carcinomatosis)
05/01/1996 - "Thus, expression of elevated levels of PKC-beta 1 and PKC-beta 2 in differentiated HD3 colon carcinoma cells blocked their differentiation, enabled them to proliferate in response to basic FGF like undifferentiated cells, increased their growth rate in athymic mice, and activated several MBP kinases, among them, p57 MAP kinase."
03/01/1994 - "Two of these colon carcinoma cell lines, U9 and HD3, which activate approximately equal amounts of TGF-beta 1 and express equal amounts of TGF-beta receptors, are now used to compare the effects of TGF-beta 1 in modulating invasive behavior. "
09/01/1994 - "In this report, we have examined the role of nm23 in two HT29 colon carcinoma sublines at different stages in tumor progression with different responses to TGF beta 1: the HD3 subline, which shows TGF beta 1-induced growth arrest and differentiation; and the more invasive and tumorigenic U9 subline, which induces tumors 7-fold as large as those induced by HD3 cells with one-half the latency. "
09/01/1995 - "In an earlier study we decreased nm23 mRNA levels 2- to 8-fold by antisense phosphorothiolated oligonucleotides in two HT29 colon carcinoma sublines at different stages in tumor progression with different responses to TGF beta 1: the HD3 subline, which shows TGF beta 1-induced growth arrest and differentiation; and the more tumorigenic U9 subline, whose growth and invasion are stimulated by TGF beta 1. Only TGF beta 1-mediated responses in HD3 cells were inhibited by nm23 antisense oligos, suggesting that nm23 functions in only one TGF beta 1 signaling pathway. "
05/01/1996 - "When HD3 colon carcinoma cells differentiate to fluid-transporting, enterocytic-like cells, they down-regulate their protein kinase C (PKC) beta levels 5-10-fold and lose two responses to basic fibroblast growth factor (FGF): proliferation and the ability to activate p57 mitogen-activated protein (MAP) kinase. "
4. Neuroectodermal Tumors (Neuroectodermal Tumor)
5. Chronic Kidney Failure (Chronic Renal Failure)

Related Drugs and Biologics

1. Transforming Growth Factor beta1 (TGF beta 1)
2. Transforming Growth Factor beta (TGF-beta)
3. Sirtuin 1
4. Messenger RNA (mRNA)
5. Oligonucleotides
6. heliomycin
7. Gangliosides
8. Antigens
9. Proteins (Proteins, Gene)
10. Hemin (Panhematin)

Related Therapies and Procedures

1. Immunotherapy
2. Therapeutics
3. Drug Therapy (Chemotherapy)
4. Aftercare (After-Treatment)
5. Tracheostomy