activin B

a glycoprotein that stimulates FSH secretion, cell differentiation, and embryonic development; a homodimer of inhibin beta B; B refers to presence of the inhibin beta B (also known as activin beta B) subunit; a member of the transforming growth factor-beta superfamily

Also Known As:

Networked: 72 relevant articles (1 outcomes, 14 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Hedger, Mark P: 5 articles (01/2017 - 01/2011)
2.	de Kretser, David M: 5 articles (01/2017 - 01/2011)
3.	Zhang, Lin: 4 articles (11/2022 - 01/2011)
4.	Zhang, Lu: 4 articles (11/2022 - 01/2011)
5.	Zhang, Min: 3 articles (11/2022 - 01/2011)
6.	Pasternack, Arja: 3 articles (01/2021 - 11/2014)
7.	Ritvos, Olli: 3 articles (01/2021 - 11/2014)
8.	Refaat, Bassem: 3 articles (01/2020 - 01/2014)
9.	Hayward, Susan: 3 articles (07/2019 - 07/2016)
10.	Phillips, David J: 3 articles (01/2016 - 01/2011)

Related Diseases

1.	Liver Cirrhosis (Hepatic Cirrhosis) 10/01/2022 - "Activin B promotes the initiation and progression of liver fibrosis." 10/01/2022 - "Hepatic and circulating activin B was increased in human patients with liver fibrosis caused by several liver diseases. " 10/01/2022 - "Neutralizing activin B largely prevented, as well as improved, CCl4 -induced liver fibrosis, which was augmented by co-neutralizing activin A. " 10/01/2022 - "Conclusions: We demonstrate that activin B, cooperating with activin A, mediates the activation or expression of JNK, iNOS, and PARP1 and the activation of HSCs, driving the initiation and progression of liver fibrosis." 10/01/2022 - "Liver and serum activin B, along with its analog activin A, were analyzed in patients with liver fibrosis from different etiologies and in mouse acute and chronic liver injury models. "
2.	Inflammation (Inflammations) 12/06/2016 - "The present study reveals the broad signaling of activin B, which is induced in non-parenchymal cells in response to hepatic inflammation, in hepatocytes." 07/12/2012 - "In the present study, we show that activin B has an unexpected but crucial role in the induction of hepcidin by inflammation. " 01/01/2017 - "Hepcidin upregulation by inflammation is independent of Smad1/5/8 signaling by activin B." 12/06/2016 - "Activin B is induced in response to inflammation in the liver and enhances hepcidin expression, but the source of activin B and the molecular mechanism underlying hepcidin induction are not clear yet. " 12/06/2016 - "Regulation of hepcidin expression by inflammation-induced activin B."
3.	Fibrosis (Cirrhosis) 01/01/2022 - "These studies lay important groundwork for the further investigation of activin B targeting as a potential therapeutic approach to attenuate kidney fibrosis. " 01/01/2022 - "In a recent issue of The Journal of Pathology, an elegant study by Sun et al identified upregulation of INHBB, the subunit of activin B, in three different models of kidney fibrosis, as well as in human kidneys with fibrosis. " 01/01/2022 - "Activin B, a new player in kidney fibrosis?†." 01/01/2022 - "Activin B, a member of the TGF-β family, exists as a homodimer of inhibin subunit beta B (INHBB), but its role in renal fibrosis remains unknown. " 11/01/2014 - "Upregulation of activin-B and follistatin in pulmonary fibrosis - a translational study using human biopsies and a specific inhibitor in mouse fibrosis models."
4.	Endometrial Neoplasms (Endometrial Cancer) 06/28/2016 - "Our previous studies have shown that activin B increases the migration of type II endometrial cancer cell lines. " 10/13/2015 - "In the present study, we examined the biological functions of activin B in type II endometrial cancer cell lines, HEC-1B and KLE. " 10/13/2015 - "However, little is known about the specific roles and mechanisms of activin B (βB dimer) in serous endometrial cancer growth and progression. " 06/28/2016 - "Histopathological studies of type II endometrial cancers (non-endometrioid, mostly serous) suggest overproduction of activin B and down-regulation of E-cadherin, both of which are associated with reduced survival. " 06/28/2016 - "We have identified a novel SMAD-independent pathway linking enhanced activin B signaling to reduced E-cadherin expression and increased migration in type II endometrial cancer."
5.	Wounds and Injuries (Trauma) 11/01/2022 - "Furthermore, Cdc42N17-transfected ADSCs inhibited the wound closure rate and suppressed the expression of CD31 and α-SMA induced by activin B in vivo. " 01/01/2017 - "These results suggest that combined treatment with activin B and ADSCs is a promising therapeutic strategy for the management of serious skin wounds." 01/01/2017 - "Moreover, activin B in combination with ADSCs boosted angiogenesis in the wound area. " 01/01/2017 - "In vivo, activin B in combination with ADSCs was capable of enhancing α-SMA expression and wound closure. " 01/01/2011 - "Activin B efficiently stimulated the proliferation of keratinocytes and hair follicle cells at the wound area and promoted wound closure. "

Related Drugs and Biologics

1.	activin A
2.	Follistatin
3.	Activins (Activin)
4.	Hepcidins
5.	Interleukin-6 (Interleukin 6)
6.	Proteins (Proteins, Gene)
7.	Oxyntomodulin
8.	Glicentin
9.	Proglucagon (Glucagon Precursors)
10.	Glucagon-Like Peptide 1 (GLP 1)

Related Therapies and Procedures

1.	Adjuvant Chemotherapy
2.	Therapeutics
3.	Immunomodulation
4.	Artificial Respiration (Mechanical Ventilation)
5.	Lasers (Laser)