Ro 22-6923

RN given refers to (5Z,11alpha,13E,15R)-isomer; structure given in first source

Also Known As:

15-acetyloxy-11,16,16-trimethyl-9-oxoprosta-5,13-dien-1-oic acid; 15-acetyltrimoprostil; Ro-22-6923

Networked: 7 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Lipids: 114793
- Fatty Acids: 27405
  - Unsaturated Fatty Acids: 8236
    - Eicosanoids: 3262
      - Prostaglandins: 17100
        Synthetic Prostaglandins: 823
        Synthetic Prostaglandins E: 6
        Ro 22-6923: 7
Biological Factors: 2472
- Inflammation Mediators: 1113
  - Synthetic Prostaglandins: 823
    - Synthetic Prostaglandins E: 6
      - Ro 22-6923: 7
  - Autacoids: 276
    - Eicosanoids: 3262
      - Prostaglandins: 17100
        Synthetic Prostaglandins: 823
        Synthetic Prostaglandins E: 6
        Ro 22-6923: 7

Related Diseases

1.	Stomach Ulcer (Gastric Ulcer) 09/01/1987 - "Hence, in the present study, the effects of pirenzepine, cimetidine, disodium cromoglycate, OKY-046 (a thromboxane A2 synthesis inhibitor), BM 13.177 (a thromboxane A2 receptor antagonist), FPL 55712 (a leukotriene C4 antagonist) and a synthetic trimethylprostanoid, Ro 22-6923 have been studied on the gastric ulcers produced by indomethacin and its combination with morphine in rats. "
2.	Peptic Ulcer (Peptic Ulcers) 01/01/1985 - "The results suggest that Ro 22-6923 may be a useful therapeutic agent for peptic ulcer disease in humans." 04/01/1985 - "The results indicate that Ro 22-6923 is a potent, long-acting antisecretory drug that may be useful in the therapy of peptic ulcer disease in man." 01/01/1985 - "The results on the antisecretory and cytoprotective properties of Ro 22-6923 suggest this drug could be potentially useful in the pharmacotherapy of peptic ulcer disease." 10/01/1986 - "These observations suggest that Ro 22-6923 exerts its anti-ulcer effects by its antisecretory, gastric mucosal resistance increasing and cytoprotective activities and that it may be a useful therapeutic agent for the treatment of peptic ulcer disease in humans."
3.	Ulcer 10/01/1986 - "These observations suggest that Ro 22-6923 exerts its anti-ulcer effects by its antisecretory, gastric mucosal resistance increasing and cytoprotective activities and that it may be a useful therapeutic agent for the treatment of peptic ulcer disease in humans." 10/01/1986 - "Gastric antisecretory, gastric and duodenal anti-ulcer and cytoprotective properties of Ro 22-6923, a synthetic trimethyl prostanoid in rats." 12/01/1985 - "To assess the potential for such an interaction with the synthetic anti-ulcer prostanoid (8R,11R,12S,15R,5Z,13E)-15-(acetyloxy)-11, 16,16-trimethyl-9-oxoprosta-5,13-dien-1-oic acid (1; Ro 22-6923), we studied the effect of Mylanta and DiGel liquid on the gastric antisecretory activity of this drug in dogs. " 09/01/1987 - "Only naloxone, FPL 55712 and Ro 22-6923 significantly reduced the morphine-potentiated ulcerogenic response of indomethacin as compared to the indomethacin ulcers in the groups pretreated with these drugs. "
4.	Wounds and Injuries (Trauma) 10/01/1986 - "Ro 22-6923, a synthetic trimethyl prostanoid, has been studied for its ability to inhibit gastric secretion and to protect the gastroduodenal mucosa against the injuries caused by pyloric ligation, hypothermic restraint stress, nonsteroidal anti-inflammatory drugs (NSAIDs), reserpine, dimaprit, cysteamine and the cytodestructing agents--80% ethanol, 0.6 M HCl, 0.2 M NaOH, 25% NaCl, aspirin 30 mg in 0.35 M HCl and 100 mM sodium taurocholate in 0.2 M HCl. "
5.	Gastric Fistula 01/01/1985 - "Ro 22-6923 inhibited basal acid secretion when administered intragastrically or intraduodenally to animals with a gastric fistula. "

Related Drugs and Biologics

1.	Prostaglandin H2 Thromboxane A2 Receptors
2.	Leukotriene C4
3.	Thromboxane A2 (A2, Thromboxane)
4.	Pirenzepine
5.	Morphine (MS Contin)
6.	Indomethacin (Indometacin)
7.	Cromolyn Sodium (Cromoglicic Acid)
8.	Cimetidine (Biomet)
9.	sulotroban
10.	ozagrel

Related Therapies and Procedures

1.	Therapeutics
2.	Ligation
3.	Drug Therapy (Chemotherapy)