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echinoside A

RN given refers to Na salt; structure given in first source

Also Known As:

holothurin A2

Networked: 4 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Carbohydrates: 22023
- Glycosides: 2119
  - Saponins: 2867
    - Holothurin: 5
      - echinoside A: 4
Biological Factors: 2472
- Biological Toxins: 20
  - Marine Toxins: 124
    - Holothurin: 5
      - echinoside A: 4

Experts

1.	Dong, Ping: 2 articles (07/2020 - 01/2014)
2.	Wang, Yuming: 2 articles (07/2020 - 01/2014)
3.	Xue, Changhu: 2 articles (07/2020 - 01/2014)
4.	Chi, Naiqiu: 1 article (07/2020)
5.	Chu, Yanyan: 1 article (07/2020)
6.	Han, Xiuqing: 1 article (07/2020)
7.	Li, Rong: 1 article (07/2020)
8.	Li, Zhaojie: 1 article (07/2020)
9.	Wang, Chengcheng: 1 article (07/2020)
10.	Zhang, Tiantian: 1 article (07/2020)

Related Diseases

1.	Non-alcoholic Fatty Liver Disease 07/01/2020 - "Relationship between structure and efficacy of sea cucumber saponins echinoside A and its derivatives on hemolytic activity and prevention of nonalcoholic fatty liver disease." 07/01/2020 - "The aim of this study was to reduce the hemolytic activity of sea cucumber-derived saponins echinoside A (EA) and simultaneously remain its effect on alleviating non-alcoholic fatty liver disease (NAFLD) by structural modifications. "
2.	Neoplasms (Cancer) 03/01/2010 - "Echinoside A inhibited the growth of tumors in mouse models and human prostate carcinoma xenografts in nude mouse models. " 10/01/2018 - "Inhibition of MDM2 triggers apoptosis through regulation of tumor protein 53 and CXCR4 inhibition may prevent cancer cell proliferation and growth by affecting the Janus kinase 2/3 signal transducer and activator of transcription signaling pathway and protein tyrosine kinase 2. The results of a binding affinity analysis using molecular docking revealed that philinopside E and ds-echinoside A may inhibit MDM2 and CXCR4. "
3.	Obesity 01/01/2014 - "Two similarly sulfated triterpene saponins from Pearsonothuria graeffei were prepared to investigate the anti-obesity effects of echinoside A (EA) and holothurin A (HA). " 01/01/2014 - "Effects of two sulfated triterpene saponins echinoside A and holothurin A on the inhibition of dietary fat absorption and obesity reduction."
4.	Carcinoma (Carcinomatosis) 03/01/2010 - "Echinoside A inhibited the growth of tumors in mouse models and human prostate carcinoma xenografts in nude mouse models. "

Related Drugs and Biologics

1.	Saponins
2.	Janus Kinase 2
3.	Focal Adhesion Kinase 1
4.	Triterpenes
5.	Proteins (Proteins, Gene)
6.	Dietary Fats (Dietary Fat)
7.	Philinopside E
8.	holothurin A