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2-cyano-3-(1-phenylindol-3-yl)acrylate

inhibits pyruvate transport into mitochondria

Also Known As:

2-CPIYA; UK 5099; UK-5099; alpha-cyano-beta-(1-phenylindol-3-yl)acrylate

Networked: 4 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Carboxylic Acids: 973
  - Acyclic Acids
    - Acrylates: 212
      - 2-cyano-3-(1-phenylindol-3-yl)acrylate: 4

Experts

1.	Buyse, Chloé: 1 article (08/2021)
2.	Corbet, Cyril: 1 article (08/2021)
3.	Feron, Olivier: 1 article (08/2021)
4.	Flament, Julien: 1 article (08/2021)
5.	Gallez, Bernard: 1 article (08/2021)
6.	Joudiou, Nicolas: 1 article (08/2021)
7.	Mignion, Lionel: 1 article (08/2021)
8.	Alves, Débora S: 1 article (01/2021)
9.	Christofk, Heather R: 1 article (01/2021)
10.	Ding, Hui: 1 article (01/2021)

Related Diseases

1.	Neoplasms (Cancer) 08/25/2021 - "CEST-MRI provided high resolution parametric images (0.44 µL/voxel) of pHe highlighting the heterogeneity of response within the tumor when exposed to UK-5099." 08/25/2021 - "Mice bearing the 4T1 tumor model were treated daily during four days with UK-5099 (3 mg/kg). " 08/25/2021 - "In the present study, we evaluated the impact of a treatment with UK-5099, a mitochondrial pyruvate carrier (MPC) inhibitor on tumor extracellular pH (pHe); (2) Methods: glucose consumption, lactate secretion and extracellular acidification rate (ECAR) were measured in vitro after exposure of cervix cancer SiHa cells and breast cancer 4T1 cells to UK-5099 (10 µM). "
2.	Uterine Cervical Neoplasms (Cancer of the Cervix) 08/25/2021 - "In the present study, we evaluated the impact of a treatment with UK-5099, a mitochondrial pyruvate carrier (MPC) inhibitor on tumor extracellular pH (pHe); (2) Methods: glucose consumption, lactate secretion and extracellular acidification rate (ECAR) were measured in vitro after exposure of cervix cancer SiHa cells and breast cancer 4T1 cells to UK-5099 (10 µM). "
3.	Breast Neoplasms (Breast Cancer) 08/25/2021 - "In the present study, we evaluated the impact of a treatment with UK-5099, a mitochondrial pyruvate carrier (MPC) inhibitor on tumor extracellular pH (pHe); (2) Methods: glucose consumption, lactate secretion and extracellular acidification rate (ECAR) were measured in vitro after exposure of cervix cancer SiHa cells and breast cancer 4T1 cells to UK-5099 (10 µM). "
4.	Hepatocellular Carcinoma (Hepatoma) 03/01/2017 - "Rat N1-S1 hepatoma cells were assayed in vitro using the Seahorse XF analyzer to measure extracellular acidification (lactate excretion) comparing effects of the addition of caffeic acid (CA) or ferulic acid (FA) or UK-5099 with control. "
5.	Fever (Fevers) 01/01/2021 - "Intracerebroventricular administration of UK 5099 reduced the LPS-induced fever. " 01/01/2021 - "Therefore, we investigated the effect of UK 5099, a classical MPC inhibitor, in a rat model of fever, on hypothalamic mitochondrial function and neuroinflammation in LPS-stimulated preoptic area (POA) primary microcultures. "

Related Drugs and Biologics

1.	Monocarboxylic Acid Transporters
2.	Lactic Acid (Lactate)
3.	Glucose (Dextrose)
4.	caffeic acid
5.	ferulic acid (sodium ferulate)