RA V

08/01/2015 - "Hence, the present study aimed to investigate the effects of RA-V on cell adhesion, migration, invasion and matrix degradation, and its underlying mechanism in two human breast cancer cell lines MCF-7 (ER-positive) and MDA-MB-231 (ER-negative). "
08/01/2015 - "RA-V inhibits breast cancer cell migration, adhesion and ECM degradation in vitro, implying that RA-V is a potential anti-metastatic agent in breast cancer, and likely acts via PI3K/AKT and NF-κB signaling pathways in both ER-positive and ER-negative breast cancer cells."
02/15/2013 - "RA-V significantly inhibited the growth of human breast cancer MCF-7, MDA-MB-231 cells and murine breast cancer 4T1 cells. "
02/15/2013 - "Taken together, this study shows that RA-V, which can induce mitochondria-mediated apoptosis, exerts strong anti-tumor activity against human breast cancer. "
02/15/2013 - "Furthermore, RA-V-induced apoptosis could be enhanced by phosphatidylinositol 3-kinase inhibitor or attenuated by over-expression of AKT in all the three kinds of breast cancer cells. "

07/01/2003 - "Addition of RA or TPA improved NB cell survival under conditions of hypoxia/metabolite deprivation (8.4 +/- 0.3 mm v 4.8 +/- 0.2 mm; RA v control at 24 hours, P <.05). "

11/16/2018 - "RA-V is thus a drug candidate for cancers involving YAP/TAZ activation."
01/01/2017 - "The organelle-specific and spatiotemporally controlled release of Dox and RA-V led to enhanced therapeutic outcomes in MDR tumor. "
02/15/2013 - "The underlying anti-cancer mechanism of RA-V is related to the blockage of the interaction between PDK1 and AKT."
02/15/2013 - "Taken together, this study shows that RA-V, which can induce mitochondria-mediated apoptosis, exerts strong anti-tumor activity against human breast cancer. "
11/16/2018 - "Furthermore, RA-V not only inhibits liver tumorigenesis induced by YAP activation, but also induces regression of established tumors. "

11/16/2018 - "Furthermore, RA-V also induces apoptosis and inhibits proliferation of macrophages in the microenvironment, which are essential for YAP-induced tumorigenesis. "
11/16/2018 - "Furthermore, RA-V not only inhibits liver tumorigenesis induced by YAP activation, but also induces regression of established tumors. "
11/16/2018 - "Cyclopeptide RA-V Inhibits Organ Enlargement and Tumorigenesis Induced by YAP Activation."

01/01/2018 - "Moreover, RA-V prevented endotoxin shock and inhibited NF-κB activation and tumor growth in vivo. "