|1.||Pomper, Martin G: 6 articles (01/2012 - 01/2005)|
|2.||Balatoni, Julius: 6 articles (05/2007 - 01/2002)|
|3.||Wang, Hsin-Ell: 5 articles (11/2015 - 01/2004)|
|4.||Finn, Ronald: 5 articles (09/2006 - 01/2002)|
|5.||Hwang, Jeng-Jong: 4 articles (11/2015 - 01/2004)|
|6.||Foss, Catherine A: 4 articles (10/2008 - 01/2005)|
|7.||Ponomarev, Vladimir: 4 articles (05/2007 - 01/2002)|
|8.||Blasberg, Ronald: 4 articles (01/2005 - 01/2002)|
|9.||Tjuvajev, Juri Gelovani: 4 articles (01/2005 - 01/2002)|
|10.||Bettegowda, Chetan: 3 articles (11/2014 - 01/2005)|
09/01/2008 - "Biodistribution studies showed a tumor uptake of 1.8+/-0.4% ID/g after 30 min. The half-life of [(131)I]FIAU in blood was 43+/-2 min. Microautoradiography showed a modest accumulation of [(125)I]FIAU in proliferating cells of small intestine, spleen and tumor. "
03/01/2007 - "The goal of this study is to image EBV-associated tumors by induction of viral TK expression with radiolabeled 2'-fluoro-2'-deoxy-beta-D-5-iodouracil-arabinofuranoside (FIAU). "
07/01/2005 - "Cell uptake and biodistribution studies indicated that [(125/123)I]L-FIAU did not show any high accumulation (sensitivity) or uptake ratios (selectivity) in HSV1-TK-positive (RG2TK+) tumors as compared to control tumors. "
07/01/2005 - "In vivo studies including biodistribution and SPECT were performed in RG2TK+ and RG2TK- tumor-bearing nude mice using [(123)I]D- and L-FIAU. "
06/01/2015 - "The intracellular accumulation of the radiolabeled tracer [(123)I]FIAU promoted by HSV-1 TK specifically pinpoints the location of tumor cells which can be imaged in vivo by SPECT. "
|2.||Glioblastoma (Glioblastoma Multiforme)
03/01/2001 - "In contrast, the recurrent glioblastoma revealed relatively high levels of [(124)I]FIAU-derived radioactivity (5-10 min after injection; 0.001 %ID/g; SUV, 0.8), which cleared slowly over the 68-h imaging period. "
09/01/2001 - "We used positron-emission tomography (PET) with I-124-labelled 2'-fluoro-2'-deoxy-1b-D-arabino-furanosyl-5-iodo-uracil ([124I]-FIAU)-a specific marker substrate for gene expression of HSV-1-tk-to identify the location, magnitude, and extent of vector-mediated HSV-1-tk gene expression in a phase I/II clinical trial of gene therapy for recurrent glioblastoma in five patients. "
03/01/2001 - "The course of biodistribution of [(124)I]FIAU was investigated in anesthetized cats (n = 3; organs) and in one patient with a recurrent glioblastoma (plasma and brain) by PET imaging over several hours (cats, 1-22 h) to several days (patient, 1-68 h). "
03/01/2001 - "However, substantial levels of [(124)I]FIAU-derived radioactivity may occur within areas of BBB disruption (e.g., glioblastoma), which is an essential prerequisite for imaging clinically relevant levels of HSV-1-tk gene expression in brain tumors after gene therapy by FIAU PET. "
06/01/2001 - "In HSV1-tk expressing cells, [3H]acyclovir showed approximately a twofold higher tracer accumulation, the [18F]FHPG uptake increased by about sixfold and the [125I]FIAU accumulation increased by about 28-fold after 120-min incubation of T1115 human glioblastoma cells. "
03/01/2012 - "The infection model in BALB/c mice was imaged with [(125)I]FIAU or [(18)F]FLT using small-animal Single Photon Emission Computed Tomography (SPECT) or Positron Emission Tomography (PET), respectively. "
01/01/2012 - "[(125)I]FIAU imaging in a preclinical model of lung infection: quantification of bacterial load."
01/01/2007 - "All patients with proven musculoskeletal infections demonstrated positive [(124)I]FIAU-PET/CT signals in the sites of concern at two hours after radiopharmaceutical administration. "
01/01/2007 - "Eight subjects with suspected musculoskeletal infections and one healthy control were studied by a combination of [(124)I]FIAU-positron emission tomography and CT ([(124)I]FIAU-PET/CT). "
01/25/2005 - "Accordingly, we demonstrated that localized infections caused by representatives of five genera of bacteria could be readily imaged with [125I]FIAU. "
|4.||Chronic Hepatitis B
10/26/1995 - "We describe severe and unexpected multisystem toxicity that occurred during a study of the antiviral nucleoside analogue fialuridine (1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-5-iodouracil, or FIAU) as therapy for chronic hepatitis B virus infection. "
10/26/1995 - "Fifteen patients with chronic hepatitis B were randomly assigned to receive fialuridine at a dose of either 0.10 or 0.25 mg per kilogram of body weight per day for 24 weeks and were monitored every 1 to 2 weeks by means of a physical examination, blood tests, and testing for hepatitis B virus markers. "
02/01/1995 - "Clinical course of four patients receiving the experimental antiviral agent fialuridine for the treatment of chronic hepatitis B infection."
01/01/1995 - "Phase I and II studies have also shown a potent in vivo antiviral effect of fialuridine and lamivudine in patients with chronic hepatitis B. "
02/01/1995 - "Effects of fialuridine on hepatitis B immune globulin pharmacokinetics following orthotopic liver transplant for chronic hepatitis B viral-induced cirrhosis."
03/01/1997 - "We systematically evaluated pre- and post-therapy biopsy, explant, and autopsy specimens from the 15 patients involved in this trial to define the hepatic changes of fialuridine toxicity and to determine whether the degree of pre-existing hepatitis contributed to the severity of toxicity. "
01/01/1997 - "Fialuridine (FIAU, 1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-5-iodouracil) is toxic to liver, heart, muscle, and nerve in clinical trials for chronic viral hepatitis (CH). "
|2.||Fluorodeoxyglucose F18 (Fludeoxyglucose F 18)
|10.||5- (2- iodovinyl)- 1- (2'- fluoro- 2'- deoxyuridine)
|1.||Gamma Cameras (Gamma Camera)
|2.||Heterologous Transplantation (Xenotransplantation)