S-carboxymethylsomatotropin

04/01/1993 - "This is the time at which ob/ob mouse adipocytes exhibit increased insulin resistance in response to RCM-hGH. "
09/01/1988 - "Acute effects of S-carboxymethylated human growth hormone on insulin resistance in the obese (ob/ob) mouse."
01/01/1990 - "Also, studies utilizing acute RCM-hGH treatment showed that its inhibitory effect on insulin activation of PI-PLC occurs within the same time frame as the onset of enhanced insulin resistance in the adipose tissue. "
02/01/1994 - "To determine whether pioglitazone can ameliorate GH-induced insulin resistance once it has been established, ob/ob mice were treated sc with either saline or 200 micrograms RCM-hGH for 3 days. "
02/01/1994 - "In control-fed mice, RCM-hGH increased blood glucose and plasma insulin levels, which is an expected response to GH-induced insulin resistance. "

11/01/1984 - "RCM-hGH was found to have greatly attenuated in vivo growth-promoting activity in the 9-day weight-gain test in hypophysectomized rats (approximately 1%) and to have a similar low order of in vitro activity in stimulating amino acid incorporation into the protein of the isolated rat diaphragm. "

09/01/1988 - "A threefold increase in plasma insulin concentration was observed three and six hours after RCM-hGH injection, but increased hyperglycemia was evident only after six hours. "