santalol

11/22/2013 - "The antiangiogenic effect by CD31 immunohistochemical staining indicated that α-santalol inhibited tumorigenesis by targeting angiogenesis. "
09/01/2006 - "Topical application of alpha-santalol significantly (P<0.05) decreased tumor incidence and multiplicity in all the three protocols, suggesting its chemopreventive efficacy against UVB radiation-caused tumor initiation, tumor promotion and complete carcinogenesis. "
06/01/2015 - "The present review discusses studies that support the anticancer effect and the mode of action of sandalwood oil and α-santalol in carcinogenesis. "
02/01/2005 - "alpha-Santalol, an active component of sandalwood oil, has been studied in detail in recent years for its skin cancer preventive efficacy in murine models of skin carcinogenesis; however, the mechanism of its efficacy is not defined. "
02/01/2003 - "alpha-Santalol significantly prevents papilloma development during promotion phase of 7,12-dimethylbenz(a)anthracene-TPA carcinogenesis protocol in both CD-1 and SENCAR mice, possibly by inhibiting TPA-induced ODC activity and DNA synthesis. "

07/01/2013 - "This study is designed to investigate the chemopreventive effect and molecular mechanisms of α-santalol on UVB-induced skin tumor development in SKH-1 hairless mouse, a widely used model for human photocarcinogenesis. "
02/01/2019 - "For example, the antitumour and cancer preventive properties of alpha-santalol have been shown to involve cell death induction through apoptosis and cell cycle arrest in various cancer models. "
09/01/2017 - "Furthermore, the tumor size was significantly reduced with α-santalol treatment. "
09/01/2017 - "Transdermal delivery of α-santalol reduced the tumor incidence and tumor multiplicity. "
11/22/2013 - "α-santalol significantly reduced the volume and the weight of solid tumors in prostate xenograft mouse model. "

07/01/2007 - "Studies have shown the chemopreventive effects of alpha-santalol on chemically and UVB-induced skin cancer in mice. "
02/01/2003 - "Additional experimental and clinical studies are needed to investigate the chemopreventive effect of alpha-santalol in skin cancer."
07/01/2013 - "Our data suggested that α-santalol is a safer and promising skin cancer chemopreventive agent with potential to target various pathways involved in photocarcinogenesis."
07/01/2013 - "α-Santalol, a skin cancer chemopreventive agent with potential to target various pathways involved in photocarcinogenesis."
01/01/2011 - "This review summarizes the chemopreventive effects and molecular mechanisms of α-santalol on skin cancer development in both animal models and skin cancer cell lines."

03/01/2021 - "The present study indicates that α-santalol induces autophagy by targeting the AKT-mTOR pathway in prostate cancer cells, which may serve as a protective mechanism."
03/01/2021 - "The current study was undertaken to investigate the role of autophagy in α-santalol-induced prostate cancer cell death. "
06/15/2012 - "In conclusion, the present study reveals the apoptotic effects of α-santalol in inhibiting the growth of human prostate cancer cells."
03/01/2021 - "Autophagy Induction by α-Santalol in Human Prostate Cancer Cells."
06/01/2020 - "Treatment of prostate cancer cells with alpha-santalol (20, 40 μM) resulted in the down regulation of survivin and p-AKT (s-473) expression and statistically significant reduction in total survivin levels as evidenced by survivin ELISA assay. "

08/03/2010 - "Thus, the objective of this study was to investigate effects of alpha-santalol on cell cycle progression in both p53 mutated human epidermoid carcinoma A431 cells and p53 wild-type human melanoma UACC-62 cells to elucidate the mechanism(s) of action. "
08/03/2010 - "Alpha-santalol, a chemopreventive agent against skin cancer, causes G2/M cell cycle arrest in both p53-mutated human epidermoid carcinoma A431 cells and p53 wild-type human melanoma UACC-62 cells."
01/01/2011 - "Studies have demonstrated that α-santalol could be effective against skin carcinogenesis through both induction of apoptosis via caspase activation together with dissipation of mitochondria membrane potential and cytochrome c release in A431 cells, and inhibition of cell growth via induction of G2/M phase arrest in both A431 cells and melanoma UACC-62 cells by altering multiple cell cycle regulatory proteins and complexes. "