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N- (2- guanidinoethyl)- 5- isoquinolinesulfonamide

structure given in first source

Also Known As:

HA 1004; HA-1004

Networked: 4 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Isoquinolines: 34
      - N-(2-guanidinoethyl)-5-isoquinolinesulfonamide: 4
Organic Chemicals: 133
- Amides: 2428
  - Sulfonamides: 2809
    - N-(2-guanidinoethyl)-5-isoquinolinesulfonamide: 4
- Sulfur Compounds: 278
  - Sulfones: 534
    - Sulfonamides: 2809
      - N-(2-guanidinoethyl)-5-isoquinolinesulfonamide: 4

Related Diseases

1.	Tics (Tic) 12/01/1992 - "TIC clustering was impeded by the protein kinase inhibitor H7 at 10 microM; however, the protein kinase inhibitor, HA 1004 (5 microM), did not inhibit TNF-induced clustering in TIC. "
2.	Neuroblastoma 07/10/1995 - "SH-SY-5Y human neuroblastoma cells were treated with combinations of the kinase inhibitors HA-1004, W-7 and H-7 and calcium ionophore A23187. "
3.	Carcinosarcoma 03/01/1993 - "Shape changes and chemokinesis of Walker carcinosarcoma cells: effects of protein kinase inhibitors (HA-1004, polymyxin B, sangivamycin and tamoxifen) and an inhibitor of diacylglycerol kinase (R 59022)."
4.	Bronchial Spasm 01/01/1988 - "HA 1004 also reversed a histamine-induced bronchospasm, as did albuterol, verapamil and nifedipine. "

Related Drugs and Biologics

1.	Protein Kinase Inhibitors
2.	Calcium Ionophores
3.	Diacylglycerol Kinase
4.	1- (5- Isoquinolinesulfonyl)- 2- Methylpiperazine (H 7)
5.	Verapamil (Calan)
6.	Tamoxifen
7.	Polymyxin B (Aerosporin)
8.	Phosphotransferases (Kinase)
9.	Nifedipine (Adalat)
10.	Histamine (Histamine Dihydrochloride)