|1.||Blalock, J Edwin: 2 articles (05/2015 - 07/2014)|
|2.||Wells, J Michael: 2 articles (05/2015 - 07/2014)|
|3.||Gaggar, Amit: 2 articles (05/2015 - 07/2014)|
|4.||Paige, Mikell: 2 articles (06/2014 - 11/2011)|
|5.||Wang, Kan: 2 articles (06/2014 - 11/2011)|
|6.||Shim, Y Michael: 2 articles (06/2014 - 11/2011)|
|7.||Haeggström, Jesper Z: 2 articles (07/2013 - 05/2006)|
|8.||Zhang, Jing: 2 articles (01/2013 - 01/2013)|
|9.||Xiao, Hang: 2 articles (01/2013 - 01/2013)|
|10.||Vaccarino, Viola: 2 articles (01/2013 - 01/2006)|
07/01/2013 - "Given its actions and role in MaR1 biosynthesis, this epoxide is now termed 13,14-epoxy-maresin (13,14-eMaR) and exhibits new mechanisms in resolution of inflammation in its ability to inhibit proinflammatory mediator production by LTA4 hydrolase and to block arachidonate conversion by human 12-LOX rather than merely terminating phagocyte involvement."
01/01/1999 - "LTA4 hydrolase expression during glomerular inflammation: correlation of immunohistochemical localization with cytokine regulation."
07/01/2014 - "We investigated changes to the leukotriene A4 hydrolase (LTA4H)-proline-glycine-proline (PGP) pathway and chronic inflammation in the development of COPD. "
03/01/2008 - "Attenuation of inflammation and cytokine production in rat colitis by a novel selective inhibitor of leukotriene A4 hydrolase."
02/01/2001 - "Therapeutic agents which selectively inhibit LTA4 hydrolase would block the formation of LTB4 and thus be potentially useful for the treatment of inflammation. "
08/01/2015 - "[Study on the association between leukotriene A4 hydrolase gene polymorphism and ischemic stroke]."
08/01/2015 - "To investigate the association between polymorphism of leukotriene A4 hydrolase (LTA4H) gene among ischemic stroke patients and the related subtypes in the discordant sib pairs. "
11/01/2008 - "Genetic variation in the genes ALOX5AP (arachidonate 5-lipoxygenase-activating protein) and LTA4H (leukotriene A4 hydrolase) has previously been shown to contribute to the risk of MI (myocardial infarction) and stroke in Icelandic and Scottish populations. "
01/01/2013 - "We sequenced the promoter, exonic, and intronic regions of leukotriene A4 hydrolase (LTA4H) and arachidonate 5-lipoxygenase (ALOX5), and then genotyped five SNPs in LTA4H and four SNPs in ALOX5 among 691 cases with stroke and 732 controls from the Chinese population. "
04/01/2008 - "The recent finding that genetic variants in 5-lipoxygenase activating protein and leukotriene A4 hydrolase may confer an increased risk of ischemic stroke has implicated the leukotriene family as potential mediators of cardiovascular disease. "
|3.||Asthma (Bronchial Asthma)
08/01/2013 - "This assay was successfully applied to a Phase II clinical study for proof-of-concept of a LTA4 hydrolase inhibitor for treatment of asthma. "
10/01/2014 - "Effects of JNJ-40929837, a leukotriene A4 hydrolase inhibitor, in a bronchial allergen challenge model of asthma."
11/01/2000 - "This region harbours a number of candidate genes for asthma and atopy, including stem cell factor (SCF), leukotriene A4 hydrolase (LTA4H), thyroid receptor 2 (TR2), and signal transducer and activator of transcription 6 (STAT6). "
12/01/2014 - "Two single nucleotide polymorphisms in Leukotriene A4 hydrolase (LTA4H) gene were reported to be associated with protection from pulmonary tuberculosis in Vietnamese population. "
01/01/2015 - "In the present study we focused on SNPs in cytokine and inflammatory mediator genes: tumor necrosis factor (TNF) -308G>A (rs1800629), interleukin-10 (IL10) -819C>T (rs1800871), interferon-gamma (IFNG) +874T>A (rs2430561), and leukotriene A4 hydrolase (LTA4H) rs1978331, rs17525495 and rs2660898 in a case-control study involving 102 pulmonary tuberculosis patients and 456 controls from Mozambique. "
01/01/2014 - "This study aimed to check the involvement of lipid mediator leukotriene (LT) B4 and the activity of LTA4 hydrolase (LTA4H) in the development of arthritis induced in rats by collagen and adjuvant (CIA). "
01/01/1999 - "We investigated the role of leukotriene B4 (LTB4) in murine arthritis models using a leukotriene A4 (LTA4) hydrolase inhibitor, SA6541. "
|2.||Arachidonate 5-Lipoxygenase (5 Lipoxygenase)
|5.||Interleukin-10 (Interleukin 10)
|6.||Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
|9.||Interferon-gamma (Interferon, gamma)