alpha'- bis(3- (N,N- diethylcarbamoyl)piperidino)- 4- xylene alpha (GT-12)

enhances human blood platelet membrane integrity; A-1 is racemic and A-1C is the (meso)-isomer

Also Known As:

GT-12; alpha, alpha'-bis(3-(N,N-diethylcarbamoyl)piperidino)-4-xylene; A-1 nipecotamide; A-1C nipecotamide; BDCPX; alpha, alpha'-bis(3-(N,N-diethylcarbamoyl)piperidino)-4-xylene, dihydrobromide; alpha-alpha'-bis(3-(N-N-diethylcarbamoyl)piperidino)-p-xylene

Networked: 3 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Piperidines: 17
    - Nipecotic Acids
      - alpha'-bis(3-(N,N-diethylcarbamoyl)piperidino)-4-xylene alpha: 3
- Heterocyclic Acids
  - Nipecotic Acids
    - alpha'-bis(3-(N,N-diethylcarbamoyl)piperidino)-4-xylene alpha: 3

Related Diseases

1.	Thrombosis (Thrombus) 10/01/1988 - "In the presence of GT-12, average thrombus size and number of platelets per thrombus were both strikingly lowered. " 10/01/1988 - "In contrast to chlorpromazine, GT-12 was effective in inhibiting platelet aggregation and thrombus rate of growth at relatively low concentrations (less than 100 mumol/L) in whole blood. " 05/01/1990 - "We conclude that GT-12 is antithrombotic for Dacron graft-induced thrombus formation in vivo."
2.	Alzheimer Disease (Alzheimer's Disease) 02/01/1995 - "We have determined frequencies of the GT-12 alleles in 78 Swedish and 49 British sporadic Alzheimer's disease cases and 104 healthy elderly control subjects, to investigate if the disease associates with a particular genotype in GT-12. " 02/01/1995 - "Linkage analysis with a fourteen-allele microsatellite at D21S210 named GT-12 has proven useful in the elucidation of amyloid precursor protein gene involvement in Alzheimer's disease families, as it is closely linked to the gene. "

Related Drugs and Biologics

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