tesmilifene (DPPE)

Also Known As:

DPPE; (2-(4-benzylphenoxy)ethyl)diethylamine; BzPhOEt-diethylammonium chloride; DEPMPE; DPPE hydrochloride; N,N-diethyl-2-((4-phenylmethyl)phenoxy)-ethanamine hydrochloride; N,N-diethyl-2-((4-phenylmethyl)phenoxy)ethanamine; N,N-diethyl-2-((4-phenylmethyl)phenoxy)ethanamine hydrochloride; N,N-diethyl-2-(4-(phenylmethyl)phenoxy)ethanamine; N,N-diethyl-2-(4-(phenylmethyl)phenoxy)ethanamine hydrochloride; ethanamine, N,N-diethyl-2-(4-(phenylmethyl)phenoxy)-, (2aR-(2aalpha,4beta,4abeta,6beta,9alpha(alphaR*,betaS*),11alpha,12alpha,12aalpha,12balpha))-; tesmilifene hydrochloride

Networked: 89 relevant articles (9 outcomes, 25 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Benzene Derivatives: 17
        Phenols: 677
        Phenyl Ethers: 8
        tesmilifene: 89
- Ethers: 242
  - Phenyl Ethers: 8
    - tesmilifene: 89

Experts

1.	Batista, Alzir A: 5 articles (11/2020 - 10/2011)
2.	Caires, Antonio C F: 5 articles (01/2012 - 11/2003)
3.	Katz, Simone: 4 articles (01/2020 - 01/2012)
4.	Wu, Yan: 4 articles (11/2014 - 01/2012)
5.	Barbiéri, Clara L: 3 articles (01/2020 - 01/2017)
6.	Garcia, Daniel M: 3 articles (01/2020 - 01/2017)
7.	Longo-Maugéri, Ieda M: 3 articles (01/2020 - 01/2017)
8.	Teixeira, Daniela: 3 articles (01/2020 - 01/2017)
9.	da Silva, Danielle A M: 3 articles (01/2020 - 01/2017)
10.	Rodrigues, Elaine G: 3 articles (07/2011 - 11/2003)

Related Diseases

1.	Breast Neoplasms (Breast Cancer) 07/15/2014 - "Collectively, the results of this study provide a possible mechanism that may be relevant to the clinical results of DPPE in breast cancer trial and demonstrates DPPE as P-gp collateral sensitivity drug. " 01/15/2004 - "We report a phase III trial comparing DOX with DPPE plus DOX in metastatic or recurrent breast cancer. " 04/24/2021 - "The growth-inhibitory effect of DPPE on MCF-7 breast cancer cells was further confirmed from the colony-formation assay. " 10/01/2020 - "The cytotoxicity of compounds against lung and breast tumor cell lines was significant, where two complexes, [Ru(L3)(bipy)(dppe)]PF6 (3) and [Ru(L3)(bipy)(dppb)]PF6 (6), were selected to evaluate changes in morphology, inhibition of migration and cell death in the MDA-MB-231 lineage. " 01/01/2009 - "We show that at physiologically attainable concentrations, treatment with DPPE alone reduced tumorsphere formation and viability of CD44(+):CD24(-/low) breast cancer cells. "
2.	Neoplasms (Cancer) 02/18/2009 - "The results suggest that tesmilifene might be effective in the treatment of tumors that are resistant to natural product drugs. " 01/01/2023 - "In this initial study, nine patients treated with DPPE embolization alone before spinal tumor resection demonstrated reduction of intraoperative blood loss compared to three patients having arterial embolization with DDPE." 01/01/2021 - "PEG2kDa -PLGA4kDa systems accumulate more rapidly in the liver compared to other formulations and PEG2kDa -DPPE demonstrates a higher tumor localization. " 01/01/2007 - "Thus, the chemopotentiating effect of DPPE may be due to its phospholipidosis-inducing potential and stimulation of PS synthesis leading to an increased exposure of PS on the cell surface which could potentially enhance cancer cell clearance by phagocytes." 10/01/1997 - "If treatment with DPPE was started in nude mice with a lower tumor burden, 25 mg/kg as well as 50 mg/kg DPPE had a similar effect to 2 mg/kg CDDP, in terms of survival. "
3.	Colonic Neoplasms (Colon Cancer) 01/01/1999 - "The results obtained with SOI animal model of colon cancer demonstrated both cis- and trans-forms of DPPE had as strong an inhibitory effect on metastasis as that of cisplatinum, but with much less toxicity. " 01/01/1999 - "Efficacy of new platinum analog DPPE in an orthotopic nude mouse model of human colon cancer." 01/01/1999 - "A surgical orthotopic implantation (S.O.I.) model of the human colon cancer cell line Co-3 in nude mice was treated with two doses of the new platinum analogs {Pt(cis-dach) (DPPE).2NO3} and {Pt(trans-dach)(DPPE).2NO3}. " 01/01/2000 - "Recent in vitro studies in human colon cancer cells have linked DPPE enhancement of paclitaxel, doxorubicin and vinblastine cytotoxicity to inhibition of the P-glycoprotein (P-gp) pump. "
4.	Cardiotoxicity 03/20/2021 - "This study was intended to explore the potential ameliorative effect of date palm pollen ethanolic extract (DPPE) against DOX-induced cardiotoxicity and the mechanisms underlying it. " 03/20/2021 - "Pre-coadministration of DPPE with DOX partially ameliorated DOX-induced cardiotoxicity as DPPE improved DOX-induced body and heart weight changes and mitigated the elevated cardiac injury markers activities of serum aminotransferases, lactate dehydrogenase, creatine kinase, and creatine kinase-cardiac type isoenzyme. "
5.	Rupture 05/01/2005 - "Interestingly, rupture of endosomes following a cellular incubation with ODN-containing SAINT-2/DPPE complexes dramatically improved nuclear ODN delivery to a level that was similar to that observed for SAINT-2/DOPE complexes. " 12/04/1996 - "The [Mo(3)X(12)](3)(-) ions reacts with phosphines (PMe(3), dppe) to form products of lower nuclearity by rupture of the bridging Mo-X bonds."

Related Drugs and Biologics

1.	Doxorubicin (Adriamycin)
2.	tesmilifene (DPPE)
3.	Platinum
4.	Member 1 Subfamily B ATP Binding Cassette Transporter
5.	N-desmethylpheniramine
6.	1,2-cyclohexanediamine (dach)
7.	Isoenzymes
8.	Phosphatidylserines
9.	L-Lactate Dehydrogenase (Lactate Dehydrogenase)
10.	Creatine Kinase (Creatine Phosphokinase)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Therapeutics
3.	Transplantation
4.	Premedication