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3,3-dimethylallyl pyrophosphate

isomeric with isopentenyl pyrophosphate

Also Known As:

3,3-dimethylallyl pyrophosphate, (14)C-labeled; DMADP cpd; DMAPP; dimethylallyl diphosphate

Networked: 12 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Terpenes: 1461
    - Hemiterpenes: 4
      - 3,3-dimethylallyl pyrophosphate: 12
- Organophosphorus Compounds: 300
  - 3,3-dimethylallyl pyrophosphate: 12

Experts

1.	Ge, Deyong: 1 article (05/2016)
2.	Ma, Yanhe: 1 article (05/2016)
3.	Xue, Yanfen: 1 article (05/2016)
4.	Hirsch, Anna K H: 1 article (12/2014)
5.	Masini, Tiziana: 1 article (12/2014)
6.	Bang, S: 1 article (06/2012)
7.	Cho, H: 1 article (06/2012)
8.	Hwang, S W: 1 article (06/2012)
9.	Yang, T J: 1 article (06/2012)
10.	Yoo, S: 1 article (06/2012)

Related Diseases

1.	Cognitive Dysfunction 11/01/2022 - "The DMapp was appreciated by people with cognitive impairment. " 11/01/2022 - "DMapp: a developing promising approach to monitor symptoms progression and stimulate memory in Italian people with cognitive impairments." 11/01/2022 - "Based on recent researches on the use of natural language processing techniques for very early detection of cognitive decline and the benefits of cognitive stimulation for people with cognitive impairments, the Dementia Monitoring application (DMapp) is developed inside the Memento project. " 11/01/2022 - "Italian people with the diagnosis of mild cognitive impairment due to Alzheimer's disease or dementia due to Alzheimer's Disease with a Mini-Mental-State-Examination between 24 and 28 (inclusive) were involved in the DMapp development prototype during the Lab Trial (4 subjects) and Filed Trial (5 subjects) of the Memento project. "
2.	Dementia (Dementias) 11/01/2022 - "DMapp seems an interesting approach to monitor dementia symptoms progression and stimulate memory. " 11/01/2022 - "Based on recent researches on the use of natural language processing techniques for very early detection of cognitive decline and the benefits of cognitive stimulation for people with cognitive impairments, the Dementia Monitoring application (DMapp) is developed inside the Memento project. " 11/01/2022 - "Italian people with the diagnosis of mild cognitive impairment due to Alzheimer's disease or dementia due to Alzheimer's Disease with a Mini-Mental-State-Examination between 24 and 28 (inclusive) were involved in the DMapp development prototype during the Lab Trial (4 subjects) and Filed Trial (5 subjects) of the Memento project. "
3.	Alzheimer Disease (Alzheimer's Disease) 11/01/2022 - "Italian people with the diagnosis of mild cognitive impairment due to Alzheimer's disease or dementia due to Alzheimer's Disease with a Mini-Mental-State-Examination between 24 and 28 (inclusive) were involved in the DMapp development prototype during the Lab Trial (4 subjects) and Filed Trial (5 subjects) of the Memento project. "
4.	Neoplasms (Cancer) 01/01/2023 - "Addition of the synthesized IPP and DMAPP precursor analogs rescued cell growth of glioblastoma (U-87MG) cancer cells concurrently treated with the HMG-CoA reductase inhibitor pitavastatin, which otherwise abrogates cell growth via blocking production of IPP and DMAPP. " 04/01/2008 - "Isopentenyl diphosphate isomerase (EC 5.3.3.2, IPI) catalyzes the revisable conversion of 5-carbon isopentenyl diphosphate (IPP) and its allylic isomer dimethylallyl diphosphate (DMAPP), which are the essential precursors for isoprenoids, including anti-tumor camptothecin. " 04/30/2023 - "Creating new or shunting of existing biosynthesis pathways in different species of Nicotiana resulted in de novo or increased synthesis of different anti-tumor molecules or their derivatives or precursors including Taxadiane (~22.5 µg/g), Artemisinin (~120 μg/g), Parthenolide (~2.05 ng/g), Costunolide (~60 ng/g), Etoposide (~1 mg/g), Crocin (~400 µg/g), Catharanthine (~60 ng/g), Tabersonine (~10 ng/g), Strictosidine (~0.23 mg/g), etc. Enriching the precursor pool, especially Dimethylallyl Diphosphate (DMAPP), down-regulating other bi-product pathways, compartmentalization or metabolic shunting, or organelle-specific reconstitution of the precursor pool, might trigger the enhanced accumulation of the targeted anti-cancer alkaloid in Nicotiana."
5.	Malaria 01/01/2004 - "Animals synthesize their isoprenoids from mevalonic acid (MVA), whereas most pathogenic bacteria and the malaria parasites utilize a completely different pathway for IPP and DMAPP synthesis, the methylerythritol phosphate (MEP) pathway. " 12/11/2014 - "Important pathogens such as Mycobacterium tuberculosis and Plasmodium falciparum, the causative agents of tuberculosis and malaria, respectively, and plants, utilize the 2C-methyl-D-erythritol 4-phosphate (MEP, 5) pathway for the biosynthesis of isopentenyl diphosphate (1) and dimethylallyl diphosphate (2), the universal precursors of isoprenoids, while humans exclusively utilize the alternative mevalonate pathway for the synthesis of 1 and 2. This distinct distribution, together with the fact that the MEP pathway is essential in numerous organisms, makes the enzymes of the MEP pathway attractive drug targets for the development of anti-infective agents and herbicides. "

Related Drugs and Biologics

1.	3,3-dimethylallyl pyrophosphate
2.	isopentenyl pyrophosphate (isopentenyl diphosphate)
3.	indolepropanol phosphate (IPP)
4.	Terpenes (Terpenoids)
5.	Mevalonic Acid (Mevalonate)
6.	Enzymes
7.	Geranyltranstransferase
8.	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)
9.	Diphosphates (Pyrophosphates)
10.	Phosphates (Orthophosphate)