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physodic acid

lichen constituent

Also Known As:

physodalic acid

Networked: 8 relevant articles (0 outcomes, 3 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 3-Ring Heterocyclic Compounds
    - Dibenzoxepins
      - physodic acid: 8

Experts

1.	Studzińska-Sroka, Elżbieta: 2 articles (04/2018 - 11/2016)
2.	Avola, Rosanna: 1 article (10/2022)
3.	Cardile, Venera: 1 article (10/2022)
4.	Graziano, Adriana C E: 1 article (10/2022)
5.	Madrid, Alejandro: 1 article (10/2022)
6.	Russo, Alessandra: 1 article (10/2022)
7.	Badreldin, Amr: 1 article (01/2022)
8.	Bagheri, Leila: 1 article (01/2022)
9.	Fatehi, Pedram: 1 article (01/2022)
10.	Mohammadi, Mahshid: 1 article (01/2022)

Related Diseases

1.	Neoplasms (Cancer) 02/01/2017 - "In the present study, we investigated the cytotoxicity of three lichen secondary metabolites (atranorin, gyrophoric acid and physodic acid) on A375 melanoma cancer cell line. " 01/01/2014 - "The anti-proliferative activitiy of Hypogymnia physodes methanol extracts (ME) and its main constituents, physodalic acid (P1), physodic acid (P2), and 3-hydroxy physodic acid (P3), was tested on human cancer HeLa cell lines. " 01/05/2022 - "This review focuses on the lichen-derived metabolite gyrophoric acid and other select secondary metabolites (e.g., usnic acid, salazinic acid, physodic acid, vulpinic acid ceratinalone, flavicansone, ramalin, physciosporin, tumidulin, atranorin, parmosidone) that modulate a number of cellular pathways relevant to several biomedical diseases and disorders, including cancer, diabetes and cardiovascular disease. "
2.	Colorectal Neoplasms (Colorectal Cancer) 04/01/2018 - "Lichen-derived caperatic acid and physodic acid inhibit Wnt signaling in colorectal cancer cells." 04/01/2018 - "The aim of this study was the evaluation of the effects of lichen-derived depsides (atranorin, lecanoric acid, squamatic acid) and depsidones (physodic acid, salazinic acid) and a poly-carboxylic fatty acid-caperatic acid, on Wnt signaling in HCT116 and DLD-1 colorectal cancer cell lines. "
3.	Prostatic Neoplasms (Prostate Cancer) 10/01/2022 - "Therefore, with the aim of identifying novel agents with antigrowth and pro-apoptotic activity on prostate cancer cells, in the present study, we evaluated the effect of lichen secondary metabolite physodic acid on cell growth in human prostate cancer cells. " 10/01/2022 - "Physodic acid sensitizes LNCaP prostate cancer cells to TRAIL-induced apoptosis." 10/01/2022 - "The combination of physodic acid with other anti-prostate cancer therapies could be considered a promising strategy that warrants further investigations."
4.	Melanoma (Melanoma, Malignant) 02/01/2017 - "Although the molecular mechanism, by which apoptosis is induced by physodic acid remains unclear, and of course further studies are needed, the results here reported confirm the promising biological properties of depsidone compounds, and may offer a further impulse to the development of analogues with more powerful efficiency against melanoma cells." 02/01/2017 - "In the present study, we investigated the cytotoxicity of three lichen secondary metabolites (atranorin, gyrophoric acid and physodic acid) on A375 melanoma cancer cell line. "
5.	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia) 12/16/2021 - "Pro-Apoptotic Potential of Pseudevernia furfuracea (L.) Zopf Extract and Isolated Physodic Acid in Acute Lymphoblastic Leukemia Model In Vitro."

Related Drugs and Biologics

1.	atranorin
2.	gyrophoric acid
3.	salazinic acid
4.	Depsides
5.	Fatty Acids (Saturated Fatty Acids)
6.	Acids
7.	caperatic acid
8.	lecanoric acid
9.	depsidone
10.	physodic acid

Related Therapies and Procedures

1.	Therapeutics