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hemoglobin City of Hope

Gly replaced by Ser at position 69 of beta chain

Also Known As:

Hb City of Hope; Hemoglobin City of Hope

Networked: 4 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Blood Proteins: 12459
    - Hemoglobins: 37188
      - Abnormal Hemoglobins: 120
        hemoglobin City of Hope: 4
  - Hemeproteins: 194
    - Globins: 2716
      - Hemoglobins: 37188
        Abnormal Hemoglobins: 120
        hemoglobin City of Hope: 4

Experts

1.	Chen, Gui-Lan: 1 article (03/2019)
2.	Jiang, Fan: 1 article (03/2019)
3.	Li, Dong-Zhi: 1 article (03/2019)
4.	Li, Jian: 1 article (03/2019)
5.	Zhou, Jian-Ying: 1 article (03/2019)
6.	Cannata, Monica: 1 article (04/2015)
7.	Cassarà, Filippo: 1 article (04/2015)
8.	Giambona, Antonino: 1 article (04/2015)
9.	Leto, Filippo: 1 article (04/2015)
10.	Maggio, Aurelio: 1 article (04/2015)

Related Diseases

1.	Thalassemia 03/01/2019 - "In this study, we present a case of coinheritance of Hb City of Hope [β69(E13)Gly→Ser; HBB: c.208G>A] and β-thalassemia (β-thal), that compromises the molecular diagnosis of β-thal trait." 03/01/2019 - "Coinheritance of Hb City of Hope (HBB: c.208G>A) and β-Thalassemia: Compromising the Molecular Diagnosis of the Codons 71/72 (+A) (HBB: c.216_217insA) Mutation by Reverse Dot-Blot Hybridization." 04/01/2015 - "This work allowed us to describe the co-inheritance of three rare β hemoglobin variants with other alterations in globin genes: the β hemoglobin variant Hb Yaounde [β134(H12)Val>Ala], found for the first time in combination with ααα(anti3.7) arrangement, and the β hemoglobin variants Hb Görwihl [β5(A2)Pro>Ala] and Hb City of Hope [β69(E13)Gly>Ser], found both in association with β(0) -thalassemia. "
2.	beta-Thalassemia (Cooley's Anemia) 01/01/1989 - "This compound heterozygosity, observed for the first time in the Turkish population was characterized by a considerable increase in Hb F production, mainly of the G gamma type, as expected for a chromosome with haplotype IV. In the second family, the variant was Hb City of Hope [beta 69(E13)Gly----Ser] which was present in combination with an unknown type of beta-thalassemia. " 01/01/1989 - "Beta-thalassemia intermedia in two Turkish families is caused by the interaction of Hb Knossos [beta 27(B9)Ala----Ser] and of Hb City of Hope [beta 69(E13)Gly----ser] with beta (0)-thalassemia."
3.	Erythema Infectiosum (Fifth Disease) 09/01/2010 - "We describe the case of a compound heterozygote in trans for Hb S (Glu6Val) and Hb City of Hope (Gly69Ser) in an anemic two year-old boy with a severe immune-deficient phenotype and fatal chronic parvovirus B19 infection. "

Related Drugs and Biologics

1.	Hemoglobins (Hemoglobin)
2.	Globins
3.	Codon (Codons)
4.	hemoglobin Görwihl
5.	hemoglobin Yaounde
6.	hemoglobin Knossos