Ro 15-4513

a partial inverse agonist of benzodiazepine receptors

Also Known As:

RO-154513; Ro15-4513; ethyl-8-azido-5,6-dihydro-5-methyl-6-oxo-4H-imidazo-1,4-benzodiazepine-3-carboxylate; 4H-Imidazo(1,5-a)(1,4)benzodiazepine-3-carboxylic acid, 8-azido-5,6-dihydro-5-methyl-6-oxo-, (Z,E,E,E,E)-

Networked: 34 relevant articles (3 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Inorganic Chemicals: 9
- Nitrogen Compounds: 67
  - Azides: 384
    - Ro 15-4513: 34
Organic Chemicals: 133
- Azides: 384
  - Ro 15-4513: 34
Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzazepines: 5
      - Benzodiazepines: 8452
        Ro 15-4513: 34

Experts

1.	Homanics, Gregg E: 2 articles (01/2011 - 03/2005)
2.	Jansen, Laura A: 1 article (01/2020)
3.	Joshi, Suchitra: 1 article (01/2020)
4.	Kapur, Jaideep: 1 article (01/2020)
5.	Roden, William H: 1 article (01/2020)
6.	Amato, Russell Joseph: 1 article (06/2012)
7.	Hulin, Mary Worrel: 1 article (06/2012)
8.	Winsauer, Peter John: 1 article (06/2012)
9.	Benavides, Rodrigo A: 1 article (01/2011)
10.	Chandra, Dev: 1 article (01/2011)

Related Diseases

1.	Hepatic Encephalopathy 05/01/1993 - "Furthermore, although Ro 15-4513 and CGS 8216 significantly increased motor activity in stage 4 hepatic encephalopathy, this may reflect their partial inverse agonist properties. " 03/01/1990 - "Doses of flumazenil or Ro 15-4513 that produced these effects in rats with hepatic encephalopathy had no detectable action on either the behavior or the visual evoked responses of normal rats. " 12/01/1991 - "In hepatic encephalopathy motor activity and the composite score were improved both by 5 mg/kg Ro 15-4513 (by 293%, p less than 0.05) and by 10 mg/kg Ro 15-3505 (by 509%, p greater than 0.01), whereas vehicle and flumazenil had no effects. " 09/01/1993 - "The effects of Ro 14-7437, of the partial inverse agonist Ro 15-4513, and the inverse agonist DMCM in rats with hepatic encephalopathy grade II/III were tested. " 03/01/1990 - "Both the deficits in spontaneous motor function and visual evoked response abnormalities of rats in stages III to IV hepatic encephalopathy were significantly improved after the administration of the benzodiazepine receptor ligands flumazenil or Ro 15-4513. "
2.	Brain Diseases (Brain Disorder) 09/01/1993 - "Encephalopathy was significantly improved by Ro 15-4513, although Ro 14-7437 and vehicle had no effect. " 12/01/1991 - "To investigate whether these effects are specific for hepatic encephalopathy or just reflect a nonspecific arousal reaction, various benzodiazepine antagonists like flumazenil or with inverse agonistic properties (Ro 15-4513, Ro 15-3505) were studied in uremic encephalopathy in rats after bilateral ureteral ligation (n = 20) and compared with hepatic encephalopathy caused by thioacetamide-induced acute liver failure (n = 33). "
3.	Ataxia (Dyssynergia) 09/01/1995 - "The possible antiethanol effect of intracerebellarly microinjected Ro15-4513 was investigated using motor incoordination as the test response. " 08/16/1990 - "We conclude that this alpha-subunit is part of a cerebellar receptor subtype, selective for Ro15-4513, an antagonist of alcohol-induced motor incoordination and ataxia." 01/01/2011 - "We conclude that Ro15-4513 requires α4-containing receptors for antagonism of ethanol-induced LORR (in males) and motor ataxia." 01/01/2011 - "In both experiments, the robust Ro15-4513 antagonism of ethanol-induced motor ataxia that was observed in WT mice was absent in KO mice. " 09/01/1995 - "This suggests that attenuation of ethanol-induced motor incoordination was most likely due to the selective antiethanol effect of Ro15-4513 at the dose range used in the present investigation. "
4.	Hypothermia 11/01/1987 - "The present study addressed this issue by investigating the effect of Ro15-4513 on ethanol-induced loss of righting reflex and hypothermia in mice. " 01/01/1989 - "In contrast, although RO 15-4513 produced hypothermia by itself, it had no significant effect on ethanol - induced hypothermia. " 11/01/1987 - "Ro15-4513 differentially affects ethanol-induced hypnosis and hypothermia." 01/01/1989 - "The ability of the putative ethanol antagonist RO 15-4513 to antagonize ethanol - induced hypoactivity, hypothermia and hyperglycemia was investigated in rats. " 08/03/1987 - "Effect of an imidazobenzodiazepine, Ro15-4513, on the incoordination and hypothermia produced by ethanol and pentobarbital."
5.	Seizures (Absence Seizure) 09/01/1987 - "These data suggest administering RO 15-4513 as an alcohol antagonist to alcoholic subjects may increase the incidence of seizures." 09/01/1987 - "RO 15-4513 induces seizures in DBA/2 mice undergoing alcohol withdrawal." 02/28/1997 - "Cocaine-induced seizures were also attenuated by any dose of Ro 15-4513 used in the cocaine groups. " 06/05/1989 - "Furthermore, Ro 15-4513 (5, 10 mg/kg, i.p.), but not FG 7142 (up to 80 mg/kg, i.p.), produced clonic-tonic seizures of short duration in ethanol-withdrawal rats. " 02/28/1997 - "Ro 15-4513 is a partial inverse agonist of benzodiazepine receptors, which has been implicated in ethanol lethality and cocaine-induced seizures. "

Related Drugs and Biologics

1.	Flumazenil (Romazicon)
2.	GABA-A Receptors (GABA(A) Receptor)
3.	Ligands
4.	Ro 15-3505
5.	Ro 14-7437
6.	Ethanol (Ethyl Alcohol)
7.	Benzodiazepines
8.	Adenosine (Adenocard)
9.	Pentobarbital (Nembutal)
10.	Diazepam (Valium)

Related Therapies and Procedures

1.	Hypnosis (Mesmerism)
2.	Ligation
3.	Injections
4.	Induced Hypothermia
5.	Anesthesia