|1.||Homanics, Gregg E: 2 articles (01/2011 - 03/2005)|
|2.||Amato, Russell Joseph: 1 article (06/2012)|
|3.||Winsauer, Peter John: 1 article (06/2012)|
|4.||Hulin, Mary Worrel: 1 article (06/2012)|
|5.||Hipólide, Débora Cristina: 1 article (02/2012)|
|6.||de Carvalho, José Gilberto Barbosa: 1 article (02/2012)|
|7.||Venditti, Marco Antonio Campana: 1 article (02/2012)|
|8.||Contó, Marcos Brandão: 1 article (02/2012)|
|9.||Chandra, Dev: 1 article (01/2011)|
|10.||Rallapalli, Sundari: 1 article (01/2011)|
05/01/1993 - "Furthermore, although Ro 15-4513 and CGS 8216 significantly increased motor activity in stage 4 hepatic encephalopathy, this may reflect their partial inverse agonist properties. "
03/01/1990 - "Doses of flumazenil or Ro 15-4513 that produced these effects in rats with hepatic encephalopathy had no detectable action on either the behavior or the visual evoked responses of normal rats. "
12/01/1991 - "In hepatic encephalopathy motor activity and the composite score were improved both by 5 mg/kg Ro 15-4513 (by 293%, p less than 0.05) and by 10 mg/kg Ro 15-3505 (by 509%, p greater than 0.01), whereas vehicle and flumazenil had no effects. "
09/01/1993 - "The effects of Ro 14-7437, of the partial inverse agonist Ro 15-4513, and the inverse agonist DMCM in rats with hepatic encephalopathy grade II/III were tested. "
03/01/1990 - "Both the deficits in spontaneous motor function and visual evoked response abnormalities of rats in stages III to IV hepatic encephalopathy were significantly improved after the administration of the benzodiazepine receptor ligands flumazenil or Ro 15-4513. "
10/01/1989 - "In addition, pretreatment with RO 15-4513 (1 or 3 mg/kg, i.p.), but not TRH (30 mg/kg, i.p.), caused seizure generalization into the forebrain following inferior collicular stimulation, further verifying the proconvulsant properties of RO 15-4513. "
09/01/1987 - "These data suggest administering RO 15-4513 as an alcohol antagonist to alcoholic subjects may increase the incidence of seizures."
09/01/1987 - "RO 15-4513 induces seizures in DBA/2 mice undergoing alcohol withdrawal."
05/01/1999 - "Seizure sensitivity was significantly increased in all ethanol-treated groups compared to ethanol-naive controls, which did not exhibit any convulsive responses to this dose of Ro15-4513. "
02/28/1997 - "Cocaine-induced seizures were also attenuated by any dose of Ro 15-4513 used in the cocaine groups. "
09/01/1995 - "The possible antiethanol effect of intracerebellarly microinjected Ro15-4513 was investigated using motor incoordination as the test response. "
08/16/1990 - "We conclude that this alpha-subunit is part of a cerebellar receptor subtype, selective for Ro15-4513, an antagonist of alcohol-induced motor incoordination and ataxia."
01/01/2011 - "We conclude that Ro15-4513 requires α4-containing receptors for antagonism of ethanol-induced LORR (in males) and motor ataxia."
01/01/2011 - "In both experiments, the robust Ro15-4513 antagonism of ethanol-induced motor ataxia that was observed in WT mice was absent in KO mice. "
09/01/1995 - "This suggests that attenuation of ethanol-induced motor incoordination was most likely due to the selective antiethanol effect of Ro15-4513 at the dose range used in the present investigation. "
11/01/1987 - "The present study addressed this issue by investigating the effect of Ro15-4513 on ethanol-induced loss of righting reflex and hypothermia in mice. "
01/01/1989 - "In contrast, although RO 15-4513 produced hypothermia by itself, it had no significant effect on ethanol - induced hypothermia. "
11/01/1987 - "Ro15-4513 differentially affects ethanol-induced hypnosis and hypothermia."
01/01/1989 - "The ability of the putative ethanol antagonist RO 15-4513 to antagonize ethanol - induced hypoactivity, hypothermia and hyperglycemia was investigated in rats. "
08/03/1987 - "Effect of an imidazobenzodiazepine, Ro15-4513, on the incoordination and hypothermia produced by ethanol and pentobarbital."
06/26/1998 - "The putative alpha4 protein, as measured by DIS [3H]Ro 15-4513 binding, was also elevated in the dentate gyrus by a single shock. "
03/01/1992 - "Pretraining injections of flumazenil and Ro 15-4513 (2.5 and 10.0 mg/kg) enhanced equally, both the acquisition and the retention of a task for 1 week requiring mice to discriminate the correct arm of a T-maze, to avoid a mild electric shock. "
03/01/1992 - "Pretreatment with Ro 15-4513 also dose-dependently protected the animals from experimental amnesia, induced by the cholinergic receptor antagonist, scopolamine in a second model of memory, in which mice were required to passively avoid a dark chamber after shock. "
03/01/1997 - "Flumazenil, Ro 15-4513, pentylenetetrazole, betaCCE but not ketamine or spiradoline decreased rates of responding in the food component at doses that had little effect on rates in the stimulus-shock termination component. "
|2.||GABA-A Receptors (GABA(A) Receptor)
|5.||Ethanol (Ethyl Alcohol)
|9.||methyl 6,7- dimethoxy- 4- ethyl- beta- carboline- 3- carboxylate
|10.||gamma-Aminobutyric Acid (GABA)