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ditercalinium (ditercalinium chloride)
structure given in first source; RN given refers to parent cpd
Also Known As:
ditercalinium chloride
; NSC 335153; NSC 366241; NSC-335153; ditercalinium acetate; ditercalinium chloride, dihydrochloride; ditercalinium dimethanesulfonate; ditercalinium hydrochloride
Networked:
8
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
Fused-Ring Heterocyclic Compounds
2-Ring Heterocyclic Compounds
Indoles: 200
Carbazoles: 32
ditercalinium: 8
3-Ring Heterocyclic Compounds
Carbazoles: 32
ditercalinium: 8
Experts
1.
Carreño-Fuentes, Liliana
: 1 article (01/2009)
2.
Gallardo-Pérez, Juan Carlos
: 1 article (01/2009)
3.
Marín-Hernández, Alvaro
: 1 article (01/2009)
4.
Moreno-Sánchez, Rafael
: 1 article (01/2009)
5.
Rodríguez-Enríquez, Sara
: 1 article (01/2009)
Related Diseases
1.
Leukemia
01/01/1990 - "
The combined evidence indicates that the toxicity of Ditercalinium to murine leukemia cells (L1210) and Chinese Hamster lung cells (DC3F) is due to disruption of mitochondrial function.
"
01/01/1992 - "
In order to eliminate or at least minimize the serious drawbacks related to its toxic effects, several chemical modifications have been made to the structure of ditercalinium, and their influence has been evaluated by measuring the DNA affinities, intercalation properties, and toxicity toward leukemia cells of the newly synthesized dimers.
"
05/01/1987 - "
In fact, a stathmokinetic experiment, in which vinblastine was used to prevent cell division in exponentially growing Friend leukemia cell cultures, demonstrated that ditercalinium effectively "froze" cells in position throughout the cell cycle, in a dose-dependent fashion.
"
05/01/1987 - "
The effect of ditercalinium on cell proliferation and its interaction with DNA in situ has been investigated in the Friend leukemia cell system.
"
11/01/1986 - "
To investigate its mechanism of cytotoxicity, the effects of ditercalinium on DNA were assessed using normal (L1210) and drug-resistant (L1210/PyDi1) mouse leukemia cells.
"
2.
Neoplasms (Cancer)
06/01/1988 - "
Among the various DNA intercalating molecules prepared in our laboratory, ditercalinium, made up of two 7H-pyrido[4,3-c]carbazole rings linked by a rigid bis-ethylbipiperidine chain (NSC 366241) displays high anti-tumor properties.
"
01/01/2009 - "
The main purpose of this review is to update and analyze the effect of several antineoplastic drugs (adriamycin, apoptodilin, casiopeinas, cisplatin, clotrimazole, cyclophosphamide, ditercalinium, NSAIDs, tamoxifen, taxol, 6-mercaptopurine, and alpha-tocopheryl succinate) and energy metabolism inhibitors (2-DOG, gossypol, delocalized lipophilic cations, and uncouplers) on tumor development and progression.
"
3.
Acute Erythroblastic Leukemia (Erythroleukemia)
07/01/1989 - "
The antitumor intercalating drug ditercalinium binds preferentially to RNA in Friend erythroleukemia cells.
"
05/01/1987 - "
Cytokinetic effects of bifunctional antitumor intercalator ditercalinium on Friend erythroleukemia cells.
"
4.
Leukemia L1210
11/01/1986 - "
Effects of the bifunctional antitumor intercalator ditercalinium on DNA in mouse leukemia L1210 cells and DNA topoisomerase II.
"
5.
Decompression Sickness (Bends)
06/01/1995 - "
These results led us to investigate whether WMC26 was selectively toxic due to a specific recognition of DNA bends by repair excinucleases, as has been demonstrated with the DNA bisintercalator, ditercalinium.
"
Related Drugs and Biologics
1.
DNA (Deoxyribonucleic Acid)
2.
Intercalating Agents
3.
ditercalinium (ditercalinium chloride)
4.
Succinic Acid (Succinate)
5.
Paclitaxel (Taxol)
6.
Mercaptopurine (6 Mercaptopurine)
7.
Vinblastine (Vinblastine Sulfate)
8.
Tamoxifen
9.
RNA (Ribonucleic Acid)
10.
Gossypol