|1.||Watson, Jeannette M: 1 article (08/2009)|
|2.||Harris, Kriss: 1 article (08/2009)|
|3.||Scarr, Elizabeth: 1 article (08/2009)|
|4.||Pavey, Geoffrey: 1 article (08/2009)|
|5.||Challiss, R A John: 1 article (08/2009)|
|6.||Salah-Uddin, Hasib: 1 article (08/2009)|
|7.||Hagan, Jim J: 1 article (08/2009)|
|8.||Dean, Brian: 1 article (08/2009)|
|9.||Choi, Shinkyu: 1 article (05/2006)|
|10.||Ko, Moon-Jeong: 1 article (05/2006)|
|1.||Alzheimer Disease (Alzheimer's Disease)
03/01/1996 - "In contrast, the maximal level of oxotremorine-M stimulated [35S]GTP gamma S binding over basal was unaltered in Alzheimer's disease superior frontal cortex and significantly reduced in Alzheimer's disease hippocampus. "
03/01/1996 - "The maximal level of oxotremorine-M stimulated [35S]GTP gamma S binding over basal was significantly increased in Alzheimer's disease superior temporal cortex, suggesting an enhanced muscarinic M2 receptor-G-protein coupling efficiency in this region. "
03/01/1996 - "Oxotremorine-M stimulated [35S]GTP gamma S binding was used to assess acetylcholine muscarinic M2 receptor mediated G-protein function in superior frontal cortical, superior temporal cortical and hippocampal membranes from a series of Alzheimer's disease and matched control subjects. "
02/15/1995 - "The efficacy of acetylcholine muscarinic M2 receptor-G protein coupling was investigated in Alzheimer's disease and control neocortical membranes by measuring the effects of MgCl2 and 5'-guanylylimidodiphosphate (Gpp[NH]p) on high-affinity [3H]oxotremorine-M ([3H]OXO-M) binding. "
05/21/1999 - "Incubation of SH-SY5Y neuroblastoma cells with oxotremorine-M resulted in the translocation of both muscarinic receptors and Gq/11 into a 'light vesicle' membrane fraction. "
03/01/1998 - "Addition of oxotremorine-M to SH-SY5Y neuroblastoma cells resulted in rapid increases in the phosphorylation of FAK (t(1/2) = 2 min) and paxillin that were independent of integrin-extracellular matrix interactions, cell attachment, and the production of phosphoinositide-derived second messengers. "
04/03/1998 - "To determine whether prolonged activation of a phospholipase C-coupled receptor can lead to a down-regulation of its effector enzyme, SH-SY5Y neuroblastoma cells were incubated for 24 h with the muscarinic receptor agonist, oxotremorine-M. "
11/01/1992 - "Himbacine was a potent blocker of oxotremorine-M-mediated cyclic AMP inhibition in rat striatum (4.4 nM) and in N1E-115 neuroblastoma cells (10.6 nM), responses mediated by M4 receptors. "
05/05/2006 - "Muscarinic receptor-mediated NF-kappaB activation was confirmed by observing the translocation of the active subunit (p65) of NF-kappaB to the nucleus by the muscarinic agonist, oxotremorine M (oxoM), in SH-SY5Y neuroblastoma cells expressing muscarinic receptors that are predominantly of the M3 subtype. "
|3.||Ganglion Cysts (Ganglion)
12/01/2003 - "However, in the in-vitro epilepsy model, in which sustained epileptiform seizures were induced by the muscarinic receptor agonist oxotremorine-M in immature rat piriform cortical brain slices, SCE was a more potent and again more rapidly-acting anticonvulsant than isolated Delta9THC, but in this model, the Delta9THC-free extract also exhibited anticonvulsant activity. "
|5.||Schizophrenia (Dementia Praecox)
08/01/2009 - "The CHRM agonist (oxotremorine-M) and a CHRM1-selective agonist (AC-42) increased Galpha(q/11)-[35S]-GTPgammaS binding, with AC-42 producing responses that were approximately 50% of those maximally evoked by the full agonist, oxotremorine-M, in control and subgroups of patients with schizophrenia. "
|1.||Acetylcholine (Acetylcholine Chloride)
|2.||Muscarinic M2 Receptor
|3.||GTP-Binding Proteins (G-Protein)
|6.||Muscarinic Receptors (Muscarinic Acetylcholine Receptor)
|9.||Type C Phospholipases