lespenefril

RN given refers to (L)-isomer

Also Known As:

3,7-bis-(alpha-6-deoxymannopyranosyloxy)-5-hydroxy-2-(4-hydroxyphenyl)chromen-4-one; kaempferitrin; kaempferol 3,7-dirhamnoside; lespedin; lespenephril

Networked: 14 relevant articles (2 outcomes, 4 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrans: 130
    - Benzopyrans: 195
      - Chromones: 159
        Flavonoids: 9773
        Flavonols: 321
        Kaempferols: 1
        lespenefril: 14
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzopyrans: 195
      - Chromones: 159
        Flavonoids: 9773
        Flavonols: 321
        Kaempferols: 1
        lespenefril: 14

Experts

1.	Ku, Wei-Chi: 2 articles (01/2021 - 12/2017)
2.	Lee, Meng-Jen: 2 articles (01/2021 - 12/2017)
3.	Chen, Jiann-Yeu: 1 article (01/2021)
4.	Li, Jen-Ying: 1 article (01/2021)
5.	Sridharan, Badrinathan: 1 article (01/2021)
6.	Yang, Shu-Yu: 1 article (01/2021)
7.	Wang, Jing: 1 article (06/2019)
8.	Zhao, Qing: 1 article (06/2019)
9.	Boeing, Thaise: 1 article (01/2019)
10.	Campos, Adriana: 1 article (01/2019)

Related Diseases

1.	Pleurisy (Pleuritis) 03/23/2011 - "This study evaluated the anti-inflammatory efficacy of the crude extract (CE), the fractions derived from hexane (HEX), ethyl acetate (AcOEt), n-butanol (BuOH), and aqueous (Aq) and isolated compounds (oleanolic acid or kaempferitrin) obtained from the aerial parts of Lotus corniculatus var. São Gabriel in mice with bradykinin-induced pleurisy. "
2.	Inflammation (Inflammations) 06/01/2019 - "In conclusion, kaempferitrin inhibited cell proliferation, induced cell apoptosis, and ameliorated inflammation of RA-FLS by suppressing the NF-κB and Akt/mTOR pathways." 06/01/2019 - "Kaempferitrin inhibits proliferation, induces apoptosis, and ameliorates inflammation in human rheumatoid arthritis fibroblast-like synoviocytes."
3.	Rheumatoid Arthritis 06/01/2019 - "Kaempferitrin inhibits proliferation, induces apoptosis, and ameliorates inflammation in human rheumatoid arthritis fibroblast-like synoviocytes."
4.	Liver Neoplasms (Liver Cancer) 08/01/2023 - "This study aimed to investigate antitumour effect and possible toxicity of kaempferitrin, the major compound from ethanol extract of Chenopodium ambrosioides, in the mice model of human liver cancer xenografts. " 08/01/2023 - "Kaempferitrin, a major compound from ethanol extract of Chenopodium ambrosioides, exerts antitumour and hepatoprotective effects in the mice model of human liver cancer xenografts." 01/01/2021 - "In this paper we studied the differential protein expression profile using mass spectrometry approach in the kaempferitrin-treated conditioned medium of liver cancer cell line HepG2. "
5.	Neurodegenerative Diseases (Neurodegenerative Disease) 12/01/2017 - "Also, studies on kaempferitrin on immune related cells have been inconclusive, and people consuming extract containing kaempferitrin often happen to be at high risk of diabetes and neurodegenerative diseases. "

Related Drugs and Biologics

1.	Complex Mixtures
2.	1-Butanol (n Butanol)
3.	Oleanolic Acid
4.	Hexanes
5.	Bradykinin
6.	ethyl acetate
7.	Stigmasterol
8.	Chalcone (Benzalacetophenone)
9.	Ethanol (Ethyl Alcohol)
10.	gamma-sitosterol (beta-sitosterol)

Related Therapies and Procedures

1.	Traditional Medicine (Folk Remedies)
2.	Drug Therapy (Chemotherapy)