01/01/1989 - "Murametide given 30 min before rIL-1 beta, blocked the expected IL-1-induced fevers but not the rIL-1 beta-mediated increases of slow-wave sleep and decreases of rapid-eye-movements sleep. "
01/01/1989 - "Therefore, the effects of murametide on IL-1-induced sleep and fever responses were determined. "
04/01/1986 - "Murametide, which has been previously shown to induce secretion of circulating EP but prevents in vivo fever response, was unable to prevent an EP-induced effect on plasma metal concentrations. "
09/01/1984 - "Moreover, plasma from rabbits treated with murametide transferred into untreated recipients elicited a febrile response typical of EP fever and comparable with that induced by plasma from MDP-treated animals. "
01/01/1989 - "A methyl ester derivative of MDP (murametide; AcMur-L-Ala-D-Gln-alpha-methyl ester) blocks IL-1-induced fever, but induces IL-1 production/release. "
01/01/1989 - "A significant proportion of MDP or Murametide-treated animals, in contrast to controls, survived the MHV-3 infection. "
01/01/1989 - "MDP and a nonpyrogenic analog, Murametide, inhibited the steep elevation of serum transaminases induced by MHV-3 irrespective of whether the immunomodulators were administered before or after the infection. "
|2.||Interleukin-1 (Interleukin 1)
|3.||Immunologic Factors (Immunomodulators)