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1-methyl-2-nitroimidazole

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Nitro Compounds: 66
  - Nitroimidazoles: 565
    - 1-methyl-2-nitroimidazole: 3
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Imidazoles: 150
      - Nitroimidazoles: 565
        1-methyl-2-nitroimidazole: 3

Related Diseases

1.

Colonic Neoplasms (Colon Cancer)

12/11/1991 - "DNA damage induced in HT-29 colon cancer cells by exposure to 1-methyl-2-nitrosoimidazole, a reductive metabolite of 1-methyl-2-nitroimidazole."
12/15/1990 - "In an attempt to identify these intermediates, we examined the ability of reductive metabolites of a model 2-nitroimidazole compound, 1-methyl-2-nitroimidazole (INO2), to enhance the toxicity of melphalan (t-PAM) in HT-29 human colon cancer cells. "
05/15/1989 - "The biological effects of 1-methyl-2-nitrosoimidazole (INO), the 2 electron reduction product of biologically active 1-methyl-2-nitroimidazole, were examined in HT-29 human colon cancer cells by clonogenic assay and glutathione (GSH) determination. "

Related Drugs and Biologics

1.	1-methyl-2-nitrosoimidazole
2.	Melphalan (Alkeran)
3.	Glutathione (Reduced Glutathione)
4.	azomycin