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ZK 93426

GABA-A receptor antag

Also Known As:

5-isopropoxy-4-methyl-beta-carboline-3-carboxylic acid ethyl ester; ZK 93 426; ZK-93426

Networked: 14 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyridines: 88
    - Carbolines: 283
      - ZK 93426: 14
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Indoles: 200
      - Indole Alkaloids: 200
        Carbolines: 283
        ZK 93426: 14
  - 3-Ring Heterocyclic Compounds
    - Carbolines: 283
      - ZK 93426: 14

Related Diseases

1.	Seizures (Absence Seizure) 08/27/1985 - "Except for ZK 93 426, all drugs proved capable of dose dependently protecting gerbils from minor (myoclonic) and major (tonic-clonic) seizures induced by air blast stimulation. " 04/01/1992 - "In dogs treated with diazepam, 6 mg/kg/day p.o., for 2 weeks, severe abstinence symptoms, including seizures, were precipitated in all animals by i.v. infusion of the BZ receptor antagonists, differences being found in the type of symptoms caused by flumazenil and ZK 93426. " 07/01/1989 - "4. In dogs treated 3 times daily with diazepam, 2 mg kg-1 orally, for 2 weeks, severe abstinence symptoms were precipitated in all animals by infusion of either antagonist but differences were found in the type of the symptoms: Ro 15-1788 induced rigid postures or rigid walking with increased muscle tone, tremor, twitches and jerks, whereas ZK 93426 did not alter motility but induced generalized myoclonic jerks and tonic-clonic seizures. " 01/01/1983 - "The anticonvulsive action of lorazepam and the proconvulsive action of DMCM against picrotoxin-induced seizures and against pentylenetetrazol-induced seizures was inhibited by low doses of ZK 93426 and Ro 15-1788. "
2.	Ataxia (Dyssynergia) 01/01/1993 - "ZK 93426 reduced alcohol-induced motor incoordination in squirrel monkeys, whereas flumazenil did not. " 07/01/1989 - "2. In diazepam-naive dogs, the most prominent behavioural alterations occurring during or after i.v. infusion of Ro 15-1788 up to a dose of 20 mg kg-1 were transient sedation, ataxia, and 'hot foot' behaviour, whereas behavioural alterations observed after ZK 93426 were not different from those observed after i.v. infusion of vehicle alone. "
3.	Tremor (Tremors) 07/01/1989 - "4. In dogs treated 3 times daily with diazepam, 2 mg kg-1 orally, for 2 weeks, severe abstinence symptoms were precipitated in all animals by infusion of either antagonist but differences were found in the type of the symptoms: Ro 15-1788 induced rigid postures or rigid walking with increased muscle tone, tremor, twitches and jerks, whereas ZK 93426 did not alter motility but induced generalized myoclonic jerks and tonic-clonic seizures. "
4.	Stomach Ulcer (Gastric Ulcer) 05/01/1987 - "FG 7142 also reduced gastric ulcer formation in restrained rats maintained at 22 degrees C for 5 hr. The ability of FG 7142 to reduce restraint-stress induced gastric ulcer formation was blocked by the benzodiazepine receptor antagonist ZK 93426 and the beta-adrenoceptor antagonist propranolol. "
5.	Respiratory Insufficiency (Respiratory Failure) 01/01/1992 - "In 4 animals with morphine-induced respiratory depression, intravenous ZK 93426 failed to antagonize the respiratory effects of morphine. "

Related Drugs and Biologics

1.	Flumazenil (Romazicon)
2.	GABA-A Receptors (GABA(A) Receptor)
3.	Benzodiazepines
4.	Diazepam (Valium)
5.	2- phenylpyrazolo(4,3- c)quinolin- 3(5H)- one
6.	norharman
7.	Therapeutic Uses
8.	Scopolamine (Hyoscine)
9.	Propranolol (Inderal)
10.	Picrotoxin