|1.||Wan, Yonghong: 4 articles (06/2010 - 07/2007)|
|2.||Mitchell, Robert A: 3 articles (11/2012 - 08/2008)|
|3.||Rendon, Beatriz E: 3 articles (11/2012 - 08/2008)|
|4.||Bramson, Jonathan L: 3 articles (06/2010 - 10/2009)|
|5.||Hoon, Dave S B: 3 articles (12/2006 - 10/2003)|
|6.||Craft, Noah: 3 articles (01/2006 - 07/2005)|
|7.||Miller, Jeff F: 3 articles (01/2006 - 07/2005)|
|8.||Bruhn, Kevin W: 3 articles (01/2006 - 07/2005)|
|9.||Petrescu, Stefana M: 2 articles (06/2014 - 03/2005)|
|10.||Negroiu, Gabriela: 2 articles (06/2014 - 03/2005)|
|1.||Melanoma (Melanoma, Malignant)
07/01/2007 - "Immunization of mice with human dopachrome tautomerase (hDCT) provides greater protection against melanoma than immunization with the murine homologue (mDCT). "
06/01/2014 - "Lesional biopsies were stained with human melanoma black-45 and tyrosinase-related protein-2 to demonstrate the melanocyte lineage. "
01/15/2014 - "The macrophage migration inhibitory factor (MIF)-homologue D-dopachrome tautomerase is a therapeutic target in a murine melanoma model."
04/15/2010 - "Immunizing against a melanoma-associated Ag, dopachrome tautomerase (DCT), which normal melanocytes and glial cells also express, allowed concurrent analysis of autoimmune consequences in multiple tissues. "
10/01/2009 - "We constructed a recombinant VSV expressing human dopachrome tautomerase (hDCT) and evaluated its immunogenicity in a murine melanoma model. "
03/25/2005 - "Tyrosinase-related protein-2 and -1 are trafficked on distinct routes in B16 melanoma cells."
03/15/2001 - "DCs pulsed with KLH and mouse tyrosinase-related protein-2 peptide results in enhanced reduction of B16 melanoma metastases; the effect is most pronounced in a setting where tyrosinase-related protein-2 peptide-pulsed DCs alone are completely ineffective. "
11/01/1999 - "Tyrosinase-related protein-2 (TRP2) is an attractive model antigen for preclinical studies in C57BL/6 mice because it is naturally expressed by the murine B16 melanoma and can be recognized by self-reactive cytolytic T lymphocytes (CTL). "
01/01/1999 - "Of perhaps greater clinical interest, genetic immunization using cDNA encoding the normal, germline-encoded murine melanosomal protein tyrosinase-related protein-2 (TRP-2) resulted in delayed outgrowth of TRP-2+ B16 melanoma in mice and was associated with an in vivo activation of TRP-2-specific cytotoxic T lymphocytes. "
09/01/1985 - "Dopachrome conversion factor, purified from Cloudman S91 melanoma cells, converts dopachrome, which is orange, to a colorless compound. "
06/01/2014 - "Value of dopachrome tautomerase detection in the assessment of melanocytic tumors."
01/01/2006 - "Central nervous system tumor immunity generated by a recombinant listeria monocytogenes vaccine targeting tyrosinase related protein-2 and real-time imaging of intracranial tumor burden."
01/15/1999 - "We recently characterized two nonmutated tumor-associated Ags for the B16 murine melanoma: tyrosinase-related protein-2 (TRP-2) and the endogenous retroviral envelope protein, p15E. "
12/15/2013 - "Stable short hairpin RNA-mediated depletion of Nanog, combined with melanocyte differentiation Ag tyrosinase-related protein-2 peptide-based vaccination, resulted in complete inhibition of B16-F10 tumor growth. "
09/15/2011 - "Moreover, in vivo inhibition of autophagy by hydroxychloroquine in B16-F10 tumor-bearing mice and mice vaccinated with tyrosinase-related protein-2 peptide dramatically increased tumor growth inhibition. "
|4.||Glioblastoma (Glioblastoma Multiforme)
09/01/2003 - "A DNA vaccine expressing tyrosinase-related protein-2 induces T-cell-mediated protection against mouse glioblastoma."
09/01/2003 - "A mouse glioblastoma cell line, termed GL261, was shown to express high levels of proteins involved in melanin biosynthesis such as the tyrosinase-related protein-2 (TRP-2), which is commonly overexpressed in melanoma cells. "
|5.||Oculocutaneous Albinism (Albinism, Yellow Mutant)
01/01/2011 - "Four genes (oculocutaneous albinism II (OCA2), tyrosinase-related protein 1 (TYRP1), dopachrome tautomerase (DCT), and KIT ligand (KITLG)) implicated in human skin-color variation, have shown evidence for positive selection in Europeans and East Asians in previous SNP-scan data. "
01/01/2014 - "The sum of these findings suggests that reduced glutathione selectively disrupts the intracellular trafficking of tyrosinase and tyrosinase-related protein-1 but not dopachrome tautomerase and Pmel17 to melanosomes, which results in the attenuation of melanization, probably serving as a putative model for oculocutaneous albinism type 4. "
01/01/2015 - "Serum 25(OH)D and SNPs (n = 960) related to genes with relevance for skin pigmentation (tyrosinase [TYR], TYR-related protein 1 [TYRP1], dopachrome tautomerase [DCT], oculocutaneous albinism II [OCA2], two pore segment channel 2 [TPCN2], solute carrier family 24 A4 [SLC24A4], solute carrier family 45 A2 [SLC45A2], agouti signalling peptide [ASIP], cyclic AMP-dependent transcription factor [ATF1], microphthalmia-associated transcription factor [MITF], proopiomelanocortin [POMC], cAMP-dependent protein kinase catalytic subunit beta [PRKACB], cAMP-dependent protein kinase catalytic subunit gamma [PRKACG], cAMP-dependent protein kinase type I-alpha regulatory subunit [PRKAR1A], cAMP-dependent protein kinase type II-alpha regulatory subunit [PRKAR2A], cAMP-dependent protein kinase type II-beta regulatory subunit [PRKAR2B], tubulin beta-3 chain/melanocortin receptor 1 [TUBB3/MC1R], Cadherin-1 [CDH1], catenin beta 1 [CTNNB1], Endothelin 1 [EDN1], endothelin 3 [EDN3], endothelin receptor type B [EDNRB], fibroblast growth factor 2 [FGF2], KIT, KIT ligand [KITLG], nerve growth factor [NGF], interferon regulatory factor 4 [IRF4], exocyst complex component 2 [EXOC2], and tumor protein 53 [TP53]) were analyzed in a cohort of participants of the Ludwigshafen Risk and Cardiovascular Health Study (n = 2970). "
|2.||A-Form DNA (A-DNA)
|3.||Monophenol Monooxygenase (Tyrosinase)
|4.||Microphthalmia-Associated Transcription Factor
|6.||Stem Cell Factor
|7.||Type 1 Melanocortin Receptor
|8.||Endothelin-3 (Endothelin 3)
|10.||Proteins (Proteins, Gene)