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glyoxal bis(guanylhydrazone)

RN given refers to parent cpd

Also Known As:

glyoxal bis(guanylhydrazone) dihydrochloride

Networked: 12 relevant articles (0 outcomes, 5 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amidines: 14
  - Guanidines: 29
    - Mitoguazone: 235
      - glyoxal bis(guanylhydrazone): 12

Experts

1.	Johnson, Betty H: 1 article (01/2002)
2.	Medh, Rheem D: 1 article (01/2002)
3.	Miller, Aaron L: 1 article (01/2002)
4.	Thompson, E Brad: 1 article (01/2002)
5.	Townsend, Courtney M: 1 article (01/2002)

Related Diseases

1.	Leukemia 12/01/1963 - "[TRIAL TREATMENT OF ACUTE LEUKEMIA WITH METHYL-GLYOXAL-BIS (GUANYLHYDRAZONE)]." 07/25/1959 - "[The effect of glyoxal-bis (guanylhydrazone) on transplanted mouse leukemia]." 11/26/1966 - "[The treatment of acute leukemias with methyl-glyoxal-bis (guanylhydrazone) and its combination with 2-hydroxystilbamidine]." 02/01/1970 - "[Effectiveness of the association of prednisone, vincristine, methyl-glyoxal-bis(guanylhydrazone)(methyl-GAG) and methotrexate in monoblastic acute leukemia]."
2.	Lymphoma (Lymphomas) 06/01/1981 - "We treated 51 patients with advanced malignant lymphoma refractory to conventional therapy with methyl-glyoxal-bis(guanylhydrazone) (methyl-GAG) at doses ranging from 400 to 800 mg/sq m. " 07/01/1989 - "Mitoxantrone, cisplatin, and methyl-glyoxal bis-guanylhydrazone chemotherapy for refractory malignant lymphoma: a Southwest Oncology Group phase II trial."
3.	Ovarian Neoplasms (Ovarian Cancer) 12/01/1984 - "Phase II study of methyl-glyoxal bis-guanylhydrazone (NSC 3296) in advanced ovarian cancer."
4.	Neoplasm Metastasis (Metastasis) 01/01/1982 - "In a phase II study of methyl-glyoxal bis-guanylhydrazone (methyl-GAG) in patients with bi-dimensionally measurable metastases of renal cell cancer, 30 patients were given 500 mg/m2 weekly for at least 4 treatment cycles and were evaluable for response. "
5.	Renal Cell Carcinoma (Grawitz Tumor) 01/01/1982 - "An EORTC phase II study of methyl-glyoxal bis-guanylhydrazone in advanced renal cell cancer." 01/01/1982 - "In a phase II study of methyl-glyoxal bis-guanylhydrazone (methyl-GAG) in patients with bi-dimensionally measurable metastases of renal cell cancer, 30 patients were given 500 mg/m2 weekly for at least 4 treatment cycles and were evaluable for response. "

Related Drugs and Biologics

1.	Mitoguazone (MGBG)
2.	Mitoxantrone (Novantrone)
3.	Cisplatin (Platino)
4.	Vincristine (Oncovin)
5.	Polyamines
6.	Methotrexate (Mexate)
7.	S-Adenosylmethionine (Ademetionine)
8.	Prednisone (Sone)
9.	Glucocorticoids
10.	Folic Acid Antagonists

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Therapeutics