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Wy 41770

produced no gastric irritation in rats; structure

Also Known As:

(5H-dibenzo(a,d)cyclohepten-5-ylidene)acetic acid; Wy-41,770; Wy-41770

Networked: 5 relevant articles (1 outcomes, 0 trials/studies)

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Bio-Agent Context: Research Results

Related Diseases

1.	Inflammation (Inflammations) 07/01/1986 - "The extensive cycling of the drug in rats may explain why ileocecal inflammation occurred in this species but not in mice and dogs following prolonged oral administration of high doses of Wy-41,770. " 06/01/1984 - "A new investigational drug, Wy-41,770, was most effective in reducing all of these aspects of inflammatory disease while indomethacin, methylprednisolone, and D-penicillamine caused a less significant diminution of only some of these parameters of inflammation. "
2.	Ulcer 01/01/1988 - "Wy-41,770 induced superficial erosions only in the cecum 26 hr after a single oral dose of 250 or 500 mg/kg of the drug, progressing to ulcers after 5 days dosing with ultrastructural evidence of bacteria in the mucosa. "
3.	Synovitis 06/01/1984 - "The acute antiinflammatory, analgesic and antipyretic activity of Wy-41,770 (oral ED50S 50-170 mg/kg) was similar to aspirin; however, it was considerably more potent orally in adjuvant arthritis in the rat (ED50, 16 mg/kg) and urate-induced synovitis in the dog (ED50, 4.5 mg/kg). "
4.	Pleurisy (Pleuritis) 06/01/1984 - "Furthermore, the cellular migration characteristic of carrageenan pleurisy was not affected by Wy-41,770. "
5.	Paralysis (Palsy) 01/01/1986 - "In the rat experimental allergic encephalomyelitis (EAE) model, Wy-41,770 reduced limb paralysis at 10 and 100 mg/kg, p.o. "

Related Drugs and Biologics

1.	Investigational Drugs
2.	Penicillamine (Cuprimine)
3.	Methylprednisolone
4.	Indomethacin (Indometacin)
5.	Antipyretics
6.	Uric Acid (Urate)
7.	Mitogens
8.	Dihydrotachysterol (AT 10)
9.	Carrageenan
10.	Aspirin (Acetylsalicylic Acid)

Related Therapies and Procedures

1.	Oral Administration