10-deacetylbaccatine III

structure given in first source

Also Known As:

10-DB III; 10-deacetyl-baccatine III; 10-deacetylbaccatin III; 7,11-Methano-5H-cyclodeca(3,4)benz(1,2-b)oxet-5-one, 12b-(acetyloxy)-12-(benzoyloxy)-1,2a,3,4,4a,6,9,10,11,12,12a,12b-dodecahydro-4,6,9,11-tetrahydroxy-4a,8,13,13-tetramethyl-, (2aR-(2aalpha,4beta,4aalpha,6beta,9alpha,11alpha,12alpha,12aalpha,12balpha))-

Networked: 7 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Terpenes: 1461
    - Diterpenes: 1470
      - Taxoids: 2650
        10-deacetylbaccatine III: 7
  - Cyclic Hydrocarbons: 97
    - Alicyclic Hydrocarbons: 1
      - Cycloparaffins: 6
        Cyclodecanes
        Taxoids: 2650
        10-deacetylbaccatine III: 7

Experts

1.	Guo, Li-Qiong: 1 article (09/2014)
2.	Han, Fei: 1 article (09/2014)
3.	Kang, Lin-Zhi: 1 article (09/2014)
4.	Lin, Jun-Fang: 1 article (09/2014)
5.	Ye, Zhi-Wei: 1 article (09/2014)
6.	Zeng, Xian-Lu: 1 article (09/2014)
7.	Binscheck, T: 1 article (01/2012)
8.	Grobosch, T: 1 article (01/2012)
9.	Schwarze, B: 1 article (01/2012)
10.	Stoecklein, D: 1 article (01/2012)

Related Diseases

1.	Neoplasms (Cancer) 06/15/2009 - "Novel C-seco-taxoids were synthesized from 10-deacetylbaccatin III and their potencies evaluated against drug-sensitive and drug-resistant cancer cell lines. " 09/01/2014 - "10-Deacetylbaccatin III (10-DAB) and baccatin III are intermediates in the biosynthesis of Taxol (an anti-cancer drug) and useful precursors for semi-synthesis of the drug. " 04/01/2008 - "The quantitative changes of anti-cancer ingredients such as taxol, cephalomannine, baccatin III and 10-deacetylbaccatin III in the branches and leaves of Taxus chinensis var. mairei during one growth season were measured by HPLC. "
2.	Dehydration (Water Stress) 09/23/1999 - "[formula: see text] Enzymatic dehydration reactions to remove selectively the chemically least reactive 13-hydroxyl group of 10-deacetylbaccatin III and its derivatives 2a-c are described. " 03/01/2010 - "Baccatin III and 10-deacetylbaccatin III showed similar degradation rates with possible products being possible dehydration around the 13-hydroxy group and cleavage of the oxetane ring. "
3.	Poisoning 01/01/2012 - "Fatal poisoning with Taxus baccata: quantification of paclitaxel (taxol A), 10-deacetyltaxol, baccatin III, 10-deacetylbaccatin III, cephalomannine (taxol B), and 3,5-dimethoxyphenol in body fluids by liquid chromatography-tandem mass spectrometry."
4.	Breast Neoplasms (Breast Cancer) 01/20/1998 - "New non-cytotoxic taxanes synthesized from 10-deacetylbaccatin III and special hydrophobic acylating agents show remarkable MDR reversal activity (< or = 99.8%) against drug-resistant human breast cancer cells when co-administered with paclitaxel or doxorubicin. "

Related Drugs and Biologics

1.	Paclitaxel (Taxol)
2.	baccatin III
3.	Taxoids (Taxanes)
4.	cephalomannine
5.	Doxorubicin (Adriamycin)
6.	10-deacetyltaxol
7.	phloroglucinol dimethyl ether
8.	oxetane