cilofungin

10/01/1989 - "The efficacy of cilofungin treatment of experimental disseminated candidiasis in rabbits was examined. "
07/01/1991 - "Thus, continuous and intermittent infusion dosage regimens that elicit nonlinear saturation plasma pharmacokinetics of cilofungin were associated with increased antifungal activity against experimental disseminated candidiasis."
10/01/1989 - "Treatment of experimental disseminated candidiasis with cilofungin."
07/01/1991 - "To optimize the in vivo efficacy of this compound, we studied the effects of its linear and nonlinear pharmacokinetics during continuous versus intermittent intravenous infusion of cilofungin in the treatment of experimental disseminated candidiasis in persistently granulocytopenic rabbits. "
01/01/1992 - "Efficacy of cilofungin therapy administered by continuous intravenous infusion for experimental disseminated candidiasis in rabbits."

08/01/1991 - "We have demonstrated in a previously described murine model of gastrointestinal (GI) and systemic candidiasis that the antifungal angent cilofungin was efficacious in clearing infection of body organs when administered subcutaneously by infusion, but permitted large numbers of Candida albicans in the GI tract to persist. "
04/01/1993 - "Cilofungin's glucan synthase inhibitory activity, MIC, and effective dose 50% in a systemic infection mouse model tend to correlate for Candida albicans. "
04/01/1993 - "Comparative efficacies of cilofungin (Ly121019) and amphotericin B against disseminated Candida albicans infection in normal and granulocytopenic mice."
10/01/1992 - "The comparative efficacy of cilofungin, fluconazole and amphotericin B in disseminated Candida tropicalis infection in neutropenic mice."
05/01/1992 - "Comparison of the efficacy of cilofungin, fluconazole and amphotericin B in the treatment of systemic Candida albicans infection in the neutropenic mouse."

07/01/1991 - "Efficacy of cilofungin alone and in combination with amphotericin B in a murine model of disseminated aspergillosis."
07/01/1991 - "Cilofungin was equivalent to amphotericin B in preventing death and eradicating cerebral aspergillosis, but it did not sterilize the kidneys. "
07/01/1991 - "Cilofungin, amphotericin B, and a combination of the two drugs were compared in a model of aspergillosis in immunocompetent mice in three experiments. "
07/01/1994 - "Semisynthetic lipopeptides such as cilofungin, LY303366, L-693,989, and L-733,560 have activity in vivo against Aspergillus infections but appear to be inactive in broth dilution in vitro tests (MICs, > 128 micrograms/ml). "

10/01/1989 - "The efficacy of cilofungin (LY121019) for aortic valve endocarditis caused by Candida albicans in rabbits was studied. "
10/01/1989 - "Evaluation of cilofungin (LY121019) for treatment of experimental Candida albicans endocarditis in rabbits."

10/01/1990 - "Furthermore, efficacy of cilofungin in treatment of murine coccidioidomycosis could not be demonstrated. "