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lithium aluminum hydride

reducing agent

Also Known As:

LiAlD4; LiAlH4; lithium aluminum deuteride

Networked: 7 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Inorganic Chemicals: 9
- Aluminum Compounds: 21
  - lithium aluminum hydride: 7
- Lithium Compounds: 12
  - lithium aluminum hydride: 7

Experts

1.	Hao, Nairong: 1 article (01/2020)
2.	Li, Lianwei: 1 article (01/2020)
3.	Yang, Jinxian: 1 article (01/2020)
4.	Zaheer, Muhammad: 1 article (01/2020)
5.	Zhu, Mo: 1 article (01/2020)
6.	Chiba, Hitoshi: 1 article (03/2016)
7.	Fuda, Hirotoshi: 1 article (03/2016)
8.	Hirano, Ken-ichi: 1 article (03/2016)
9.	Hiruma, Takahisa: 1 article (03/2016)
10.	Hui, Shu-Ping: 1 article (03/2016)

Related Diseases

1.	Neoplasms (Cancer) 12/01/1990 - "This component, the least hydrophobic of the tumor-localizing fraction, was deemed to be dihematoporphyrin ether, based on mass spectrometric analysis and its behavior toward base hydrolysis and lithium aluminum hydride reduction. " 09/01/1987 - "Probing the structure and stability of the tumor-localizing derivative of hematoporphyrin by reductive cleavage with LiAlH4." 09/01/1967 - "The tumor lipid was subjected to saponification, transesterification, and lithium aluminum hydride reduction. " 09/01/1987 - "A procedure involving the use of the reducing agent lithium aluminum hydride (LiAlH4) has been designed to explore the nature of the oligomer linkages in the tumor-localizing component of hematoporphyrin derivative (HPD). "
2.	Dehydration (Water Stress) 03/01/2016 - "The principal reactions used were: (1) trans diaxial opening of 2α,3α-epoxy-6-oxo-5α-cholestane with LiAlD4 and subsequent oxidation of the resulting (2β,6α-(2)H2)-3α,6β-diol with Jones' reagent, followed by reduction of the resulting (2β-(2)H)-3,6-dione with NaBD4 leading to the (2β,3α,6α-(2)H3)-3β,6β-dihydroxy-5α-cholestane, (2) selective protection of the 3β-hydroxy group as the tert-butyldimethylsilyl ether, (3) dehydration of the 6β-hydroxy group with POCl3 and removal of tert-butyldimethylsilyloxy groups with 5M HCl in acetone, and (4) esterification of the resultant (2β,3α,6-(2)H3)cholesterol with linoleic and oleic acids using 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide. " 02/01/1996 - "Addition of a series of perfluoroalkylorganometallic reagents (RFLi; RF = C2F5, C3F7, or C4F9) to the 3 position of silylated testosterone 2b afforded delta 4 perfluoroalkyl carbinols 3. In Scheme 1, deprotection with HF and oxidation at the C-17 carbon with PCC produced delta 4 ketones 5. In Scheme 2 dehydration of 3 with 1,2-phenylenephosphorochloridite and iodine afforded delta 3,5 dienes 6 which were deprotected and oxidized as above to the C-17 ketones 8. In Scheme 3 isomerization of the double bond of 3 from the C-4 to the C-5 position using the allylic halogenation followed by treatment with lithium aluminum hydride led to the synthesis of the double bond isomer series 12. "
3.	Prion Diseases (Transmissible Spongiform Encephalopathies) 08/01/2009 - "Reduction of prion infectivity and levels of scrapie prion protein by lithium aluminum hydride: implications for RNA in prion diseases."
4.	Scrapie 08/01/2009 - "Treatment with RNase A alone and PrP degradation by RNase A plus proteinase K in vitro, however, did not result in loss of scrapie infectivity compared with the effects of lithium aluminum hydride. " 08/01/2009 - "Reduction of prion infectivity and levels of scrapie prion protein by lithium aluminum hydride: implications for RNA in prion diseases." 08/01/2009 - "Lithium aluminum hydride, a reducing agent that can induce reductive cleavage of oxidized molecules such as carbonyls, carboxyl acids, esters, and phosphodiester bonds, did not affect cellular PrP degradation; however, it destroyed PrPSc, extended the scrapie incubation period, and markedly reduced total RNA concentrations. "
5.	Conversion Disorder (Astasia Abasia) 01/01/2020 - "In this work, we investigated the chemical stability of long-subchain hyperbranched polystyrenes with ester, aryl ether, and carbon-carbon bonds as branching linkages under a few most popular PPM conditions, including NaOH hydrolysis reaction, TFA-promoted hydrolysis reaction, BBr3-catalyzed methoxy-hydroxyl conversion reaction, and LiAlH4 carbonyl reduction reaction. "

Related Drugs and Biologics

1.	Reducing Agents
2.	Indicators and Reagents (Reagents)
3.	Ether (Diethyl Ether)
4.	Esters
5.	Carbon
6.	lithium aluminum hydride
7.	Endopeptidase K (Proteinase K)
8.	Hydroxyl Radical
9.	Hematoporphyrin Derivative
10.	Dihematoporphyrin Ether (Porfimer Sodium)