2,3,4-tri-O-acetylarabinopyranosyl isothiocyanate (AITC)

02/15/2020 - "Pretreatment with AITC markedly improved oxidative stress and GSH-redox disorder in COPD. "
12/01/2021 - "These results suggest that AITC improves COPD by promoting RCT process and reducing inflammatory response via activating LXR pathways."
12/01/2021 - "AITC can improve lung function and pathological injury in COPD rats. "
12/01/2021 - "We aimed to explore whether and how AITC affects COPD by regulating lipid metabolism and inflammatory response. "
06/01/2023 - "AITC can improve the lung function of rats with COPD, restore lung tissue structure, improve oxidative stress, reduce inflammation, and inhibit lung cell apoptosis. "

01/01/2010 - "These findings suggest that AITC may be most effective in the bladder as a cancer chemopreventive compound. "
01/04/2018 - "This in vitro study warrants more preclinical and clinical studies on the beneficial and harmful effects of AITC in healthy and cancer cells."
01/01/2010 - "Overall, AITC exhibits many desirable attributes of a cancer chemopreventive agent, and further studies are warranted in order to elucidate its mechanism of action and to assess its protective activity in humans."
12/01/2023 - "Moreover, we emphasized on investigational anticancer activities and various strategies for delivery of AITC in different types of cancer. "
12/01/2023 - "In this review, we highlighted the chemopreventive attributes of AITC in relation to its molecular mechanisms and metabolic fate for cancer. "

01/01/2015 - "Therefore, the aim of this study was to investigate the effects of AITC activity on bladder cancer cell lines carrying a wild type (wt; RT4) or mutated (T24) TP53 gene. "
04/01/2019 - "The results demonstrate the potential of AITC-NPs as therapeutic agents for the treatment of bladder cancer and the enhancement of immune function. "
04/01/2019 - "However, at 2 g L-1 dosage, AITC-NPs could inhibit the growth of human bladder cancer cells HT1376 by 90%, while their low dosage at 0.25 g L-1 could inhibit migration ability by 83.7, 71.3, 58.4 and 31.4% after 4, 8, 12, and 24 h of incubation, respectively. "
02/01/2012 - "We show here that treatment of human bladder cancer UM-UC-3 cells or rat bladder cancer AY-27 cells with NAC-AITC at 15 μM results in significant inhibition of cell growth and proliferation, together with cell cycle arrest and apoptosis. "
09/16/2011 - "Here, we show that AITC arrests human bladder cancer cells in mitosis and also induces apoptosis. "

08/29/2022 - "Our findings revealed that two-week AITC treatment exacerbated oxidative and inflammation status in diabetic rats."
08/29/2022 - "The inflammation and oxidative effects were enhanced by an AITC dose increase. "
01/01/2014 - "Thus, AITC may have potential application in treating conditions marked by inflammatory-driven angiogenesis and mucosal inflammation. "
06/01/2023 - "AITC can improve the lung function of rats with COPD, restore lung tissue structure, improve oxidative stress, reduce inflammation, and inhibit lung cell apoptosis. "
01/01/2014 - "Herein, we investigated the effect of AITC on angiogenesis and inflammation in a mouse model of colitis. "

10/01/2014 - "However, the effect of AITC on insulin resistance and mitochondrial function has not yet been investigated. "
10/01/2014 - "Collectively, these data suggest that the protective effect of AITC on insulin resistance is partly mediated through the modulation of mitochondrial dysfunction. "
12/21/2021 - "Additionally, AITC at 5 mg improved insulin sensitivity (HOMA-IR index) in spite of reduced blood insulin. "
07/01/2019 - "In the present study, we investigated the effects of AITC on insulin resistance and transcription factors in a diabetic rat model. "
09/14/2019 - "Allyl isothiocyanate (AITC), a classic anti-inflammatory and antitumorigenic agent, was recently identified as a potential treatment for obesity and insulin resistance. "