|1.||Zhang, Yuesheng: 8 articles (01/2015 - 10/2003)|
|2.||Li, Yun: 5 articles (11/2013 - 02/2010)|
|3.||Carstens, Mirela Iodi: 5 articles (09/2012 - 02/2008)|
|4.||Bhattacharya, Arup: 4 articles (11/2013 - 02/2010)|
|5.||Carstens, E: 4 articles (09/2012 - 02/2008)|
|6.||Lu, Chi-Cheng: 3 articles (01/2014 - 08/2010)|
|7.||Yang, Jai-Sing: 3 articles (01/2014 - 08/2010)|
|8.||Geng, Feng: 3 articles (02/2012 - 02/2010)|
|9.||Tang, Li: 3 articles (09/2011 - 10/2003)|
|10.||Hwang, Eun-Sun: 3 articles (01/2009 - 01/2006)|
01/01/2010 - "These findings suggest that AITC may be most effective in the bladder as a cancer chemopreventive compound. "
04/01/2014 - "Therefore, further studies using other molecular targets need to be performed to better understand the mechanisms by which AITC may exert its antineoplastic properties against tumor cells."
01/01/2010 - "Overall, AITC exhibits many desirable attributes of a cancer chemopreventive agent, and further studies are warranted in order to elucidate its mechanism of action and to assess its protective activity in humans."
01/01/2015 - "These data confirm the role of AITC as a potential antiproliferative compound that modulates gene expression according to the tumor cell TP53 genotype. "
02/01/2010 - "This differential effect was explained by our finding that urinary levels of AITC equivalent were two to three orders of magnitude higher than that in the plasma and that its levels in the orthotopic cancer tissues were also three orders of magnitude higher than that in the subcutaneous cancer tissues. "
|2.||Urinary Bladder Neoplasms (Bladder Cancer)
02/01/2012 - "Furthermore, comparison of the pharmacokinetic and physical properties of NAC-AITC with those of AITC suggests that NAC-AITC is superior to AITC for potential use for prevention and therapy of bladder cancer."
01/01/2015 - "Therefore, the aim of this study was to investigate the effects of AITC activity on bladder cancer cell lines carrying a wild type (wt; RT4) or mutated (T24) TP53 gene. "
04/01/2014 - "Due to its high bioavailability in urine after ingestion, AITC has been considered a promising antineoplastic agent against bladder cancer. "
02/01/2012 - "We show here that treatment of human bladder cancer UM-UC-3 cells or rat bladder cancer AY-27 cells with NAC-AITC at 15 μM results in significant inhibition of cell growth and proliferation, together with cell cycle arrest and apoptosis. "
09/16/2011 - "Here, we show that AITC arrests human bladder cancer cells in mitosis and also induces apoptosis. "
08/15/2012 - "AITC (10mM) was approximately 3-times less effective in inducing cough than capsaicin (50 μM). "
08/15/2012 - "Consistent with the cough studies, AITC was approximately 3-times less effective than capsaicin in evoking sustained activation of the jugular C-fibers. "
11/01/2012 - "System suitability test results are as follows: AITC caused 10.7 (SEM=1.4592) coughs vs. 5.8 (SEM=1.6553) when pre-treated with HC-030031 (P<0.05). "
08/15/2012 - "Another TRPA1 agonist, cinnamaldehyde, was approximately twofold more effective than AITC in inducing cough. "
08/15/2012 - "In conscious guinea pigs the TRPA1 agonist allyl-isothiocyanate (AITC) evoked cough with a maximally effective concentration of 10mM that was abolished by the selective TRPA1 antagonist AP-18. "
01/01/2014 - "Hence, AITC may be beneficial in the treatment of human colorectal adenocarcinoma in the future."
11/01/2010 - "In this study, AITC was shown to inhibit the proliferation of human metastatic colorectal adenocarcinoma SW620 cells in vitro by inducing cell cycle arrest at the G2/M phase. "
|5.||Lung Diseases (Lung Disease)
|2.||Proteins (Proteins, Gene)
|7.||Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
|8.||Messenger RNA (mRNA)
|9.||phenethyl isothiocyanate (PEITC)
|10.||JNK Mitogen-Activated Protein Kinases
|1.||Heterologous Transplantation (Xenotransplantation)