|1.||Wakamatsu, Kazumasa: 6 articles (07/2010 - 10/2004)|
|2.||Ito, Shosuke: 5 articles (07/2010 - 10/2004)|
|3.||Warren, Warren S: 4 articles (02/2014 - 02/2011)|
|4.||Simon, John D: 4 articles (02/2014 - 01/2003)|
|5.||Wilson, Jesse W: 3 articles (02/2014 - 06/2011)|
|6.||Simpson, Mary Jane: 3 articles (02/2014 - 02/2011)|
|7.||Wolnicka-Glubisz, Agnieszka: 2 articles (02/2015 - 01/2013)|
|8.||Robles, Francisco E: 2 articles (02/2014 - 12/2013)|
|9.||Matthews, Thomas E: 2 articles (06/2011 - 02/2011)|
|10.||Diffey, Brian: 2 articles (07/2010 - 06/2005)|
|1.||Skin Neoplasms (Skin Cancer)
12/01/2002 - "Second, and opposite, loss-of-function mutations may decrease eumelanin contents, and impair protection against the carcinogenic effects of UV light, thus predisposing to skin cancers. "
01/01/2015 - "Persons with red hair have mutations in the MC1R causing its inactivation; this leads to a paucity of eumelanin production and makes red-heads more susceptible to skin cancer. "
08/20/2014 - "Despite compelling biomedical relevance to skin cancer and melanoma, eumelanin photoprotection is still an enigma: What makes this pigment so efficient in dissipating the excess energy brought by harmful UV-light as heat? "
01/01/2015 - "MC1R, eumelanin and pheomelanin: their role in determining the susceptibility to skin cancer."
09/01/2011 - "Fair skin and red hair are characterized by a low eumelanin to pheomelanin ratio, and have been associated with increased risk of skin cancer. "
|2.||Melanoma (Melanoma, Malignant)
01/01/2014 - "MC1R variants were traditionally thought to increase risk for melanoma secondary to intensified UV-mediated DNA damage in the setting of absent photoprotective eumelanin. "
09/01/2006 - "Exposure to UVR increases the synthesis of the photoprotective eumelanin on activation of MC1R, a melanoma susceptibility gene. "
08/01/2003 - "Melanotic melanomas produced pure eumelanin but in vesiculo-globular melanosomes ('pheomelanosomes'); the eumelanosomes, characteristically ellipsoidal in shape with fibrillar or fibrillo-lamelar matrix, were never noticed. "
01/01/2000 - "Since eumelanin predominates in the mouse melanoma cells and melanocytes, they are less likely than human cells to provide a satisfactory model for human solar melanomagenesis. "
09/01/1998 - "In the melanoma cell group (HBL cells cultured in media of different compositions), the chemical and morphometric estimations were not parallel in the case of eumelanins and pheomelanins. "
01/01/2015 - "Cytotoxicity of DOPA melanin against cervical cancer cell line showed a dose-response activity, and IC50 value was found to be 300 μg/mL. These results would open the way to propose Streptomyces sp. MVCS6 as a promising source of bioactive eumelanin with therapeutic potential in medicine."
06/01/2005 - "By contrast, based on measurements of eumelanin and pheomelanin in human skin, before and following irradiation, we now report that both pheomelanin and eumelanin are positively related to skin colour, and by inference, inversely with cancer susceptibility. "
09/29/2011 - "The capability to monitor finely the physical properties of eumelanin, an important class of biopolymers, involved in melanoma cancer pathologies, whose function and intrinsic disorder still collects the interest of many investigators, was achieved by means of electrospray deposition (ESD). "
11/16/2010 - "The photoactivation of oxygen by pheomelanin in the UV-A range could contribute to the development of UV-induced cancers: recent measurement of the surface photoionization threshold of intact melanosomes reveals a lower photoionization potential for pheomelanin than eumelanin. "
04/01/2005 - "Skin color, a predictor of social interactions and risk factor for several types of cancer, is due to two contrasting forms of melanin, the darker eumelanin and lighter phaeomelanin. "
|4.||Neoplasm Metastasis (Metastasis)
04/01/1992 - "Measurement of eumelanin precursor metabolites in the urine as a new marker for melanoma metastases."
04/01/1994 - "To establish a better method for the detection of occult melanoma this study compares the plasma levels of a pheomelanin metabolite, 5-S-CD, and a eumelanin metabolite, 6-hydroxy-5-methoxyindole-2-carboxylic acid (6H5MI2C), in melanoma and non-melanoma patients and correlates them with tumor thickness and melanoma metastasis. "
03/01/1993 - "Specifically, we will discuss that: 1) the synthesis of pheomelanin is markedly increased in malignant melanoma and dysplastic melanocytic nevi; 2) high levels of metabolites of pheomelanin and eumelanin can be detected in the urine and blood of patients with metastatic melanoma; 3) this release of melanin metabolites appears to correlate with tumor thickness and tumor load, including the extent of metastasis; 4) the synthesis of melanosomal proteins also becomes aberrant in malignant melanoma; and 5) this abnormal melanosome synthesis can be utilized in the identification of antigenic epitopes that are uniquely expressed in malignant melanoma. "
09/01/2003 - "Eumelanin and phaeomelanin contents of depigmented and repigmented skin in vitiligo patients."
09/01/2003 - "In a preliminary study, to quantify levels of both eumelanin and phaeomelanin in depigmented as well as repigmented patches of vitiligo following psoralen plus ultraviolet A (PUVA) therapy. "
|6.||DNA (Deoxyribonucleic Acid)