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NADH dehydrogenase (quinone)

catalyzes the oxidation of NADH to NAD with quinone as acceptor

Also Known As:

NADH quinone oxidoreductase; bacterial NDH-1; proton-translocating NADH-quinone oxidoreductase

Networked: 22 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Oxidoreductases: 13671
    - NADPH Oxidoreductases NADH
      - Quinone Reductases: 10
        NADH dehydrogenase (quinone): 22

Experts

1.	Matsuno-Yagi, Akemi: 7 articles (08/2014 - 09/2004)
2.	Yagi, Takao: 7 articles (08/2014 - 09/2004)
3.	Nakamaru-Ogiso, Eiko: 5 articles (08/2015 - 09/2004)
4.	Seo, Byoung Boo: 5 articles (12/2010 - 09/2004)
5.	Fritz, Günter: 2 articles (07/2020 - 01/2017)
6.	Steuber, Julia: 2 articles (07/2020 - 01/2017)
7.	Hyun, Dong-Hoon: 2 articles (01/2013 - 04/2012)
8.	Kim, Jiyeong: 2 articles (01/2013 - 04/2012)
9.	Mattson, Mark P: 2 articles (01/2013 - 04/2012)
10.	Marella, Mathieu: 2 articles (01/2008 - 08/2007)

Related Diseases

1.	Parkinson Disease (Parkinson's Disease) 09/01/2004 - "It has been reported that defects of mitochondrial proton-translocating NADH-quinone oxidoreductase (complex I) are involved in many human diseases (such as encephalomyopathies and sporadic Parkinson's disease). " 05/19/2006 - "Recent studies suggest that dysfunction of the NADH-quinone oxidoreductase (complex I) is associated with a number of human diseases, including neurodegenerative disorders such as Parkinson disease. " 12/06/2010 - "Defects in mitochondrial proton-translocating NADH-quinone oxidoreductase (complex I) have been implicated in a number of acquired and hereditary diseases including Leigh's syndrome and more recently Parkinson's disease. " 01/16/2008 - "It is widely recognized that mitochondrial dysfunction, most notably defects in the NADH-quinone oxidoreductase (complex I), is closely related to the etiology of sporadic Parkinson's disease (PD). "
2.	Neurodegenerative Diseases (Neurodegenerative Disease) 08/17/2007 - "Defects in the proton-translocating NADH-quinone oxidoreductase (complex I) of mammalian mitochondria are linked to neurodegenerative disorders. " 05/19/2006 - "Recent studies suggest that dysfunction of the NADH-quinone oxidoreductase (complex I) is associated with a number of human diseases, including neurodegenerative disorders such as Parkinson disease. " 08/01/2014 - "The proton-translocating NADH-quinone oxidoreductase (complex I/NDH-1) is the first and largest enzyme of the respiratory chain which has a central role in cellular energy production and is implicated in many human neurodegenerative diseases and aging. "
3.	Ischemia 08/01/2014 - "However, animal studies have shown that yeast-derived internal NADH quinone oxidoreductase (Ndi1) can be delivered as a cell-permeable recombinant protein (Tat-Ndi1) that can functionally replace complex I damaged by ischemia/reperfusion. "
4.	Mitochondrial Diseases (Mitochondrial Disease) 08/01/2015 - "Complex I (NADH:quinone oxidoreductase) is central to cellular aerobic energy metabolism, and its deficiency is involved in many human mitochondrial diseases. " 09/19/2008 - "NADH:quinone oxidoreductase (complex I) plays a central role in cellular energy metabolism, and its dysfunction is found in numerous human mitochondrial diseases. " 01/16/2008 - "It is widely recognized that mitochondrial dysfunction, most notably defects in the NADH-quinone oxidoreductase (complex I), is closely related to the etiology of sporadic Parkinson's disease (PD). "
5.	Neuroblastoma 01/01/2013 - "Here we used human neuroblastoma cells with low or high levels of the PMRS enzyme NADH-quinone oxidoreductase 1 (NQO1) to investigate how the PMRS modulates mitochondrial functions and cell survival. " 04/01/2012 - "Here, we used human neuroblastoma cells with either elevated or reduced levels of the PMRS enzyme NADH-quinone oxidoreductase 1 (NQO1) to investigate how the PMRS regulates neuronal stress responses. "

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4.	Proteins (Proteins, Gene)
5.	Antioxidants
6.	Cyclooxygenase 2 (Cyclooxygenase-2)
7.	Proliferating Cell Nuclear Antigen (PCNA)
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9.	Messenger RNA (mRNA)
10.	Protons (Proton)