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zindoxifene
structure given in first source
Also Known As:
5-acetoxy-2-(4-acetoxyphenyl)-1-ethyl-3-methylindole; D 16726; D-16762; 1H-Indol-5-ol, 2-(4-(acetyloxy)phenyl)-1-ethyl-3-methyl-, acetate (ester)
Networked:
7
relevant articles (
0
outcomes,
1
trials/studies)
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
Fused-Ring Heterocyclic Compounds
2-Ring Heterocyclic Compounds
Indoles: 200
zindoxifene: 7
Related Diseases
1.
Breast Neoplasms (Breast Cancer)
03/01/1990 - "
We conclude that zindoxifene in the doses used in this study has only marginal therapeutic activity in the treatment of advanced breast cancer.
"
03/01/1990 - "
Phase I/II study of the anti-oestrogen zindoxifene (D16726) in the treatment of advanced breast cancer.
"
02/15/1988 - "
All compounds were less active than estradiol but all derivatives including D15414, the hydroxylated metabolite of D16726 (zindoxifene, a known antitumor agent against mammary cancer) were fully estrogenic.
"
2.
Carcinoma (Carcinomatosis)
01/01/1997 - "
Their inhibition by alkylphosphocholines leads in the dimethylbenzanthracene-induced mammary carcinoma of the rat to a response pattern similar to that of the antiestrogen zindoxifene.
"
01/01/1992 - "
The effect of a combination of zindoxifene and cisplatin on Dunning R3327-G prostatic carcinomas of the rat.
"
01/01/1991 - "
The anti-oestrogen zindoxifene was originally developed as a drug for the treatment of hormone-dependent mammary carcinomas.
"
01/01/1992 - "
Therefore, we studied the effects of hormonal and cytostatic treatment in a rat prostate carcinoma model: freshly transplanted Dunning R3327-G prostatic tumours of the rat were treated with the partial antioestrogen zindoxifene and cisplatin alone and in combination.
"
07/01/1987 - "
The tumor-inhibiting activity of D 16726 and D 15413 on the androgen-dependent R 3327 Dunning prostatic carcinoma and the human prostatic tumor PC 82 implanted in nude mice equals that of castration or of diethylstilbestrol.
"
3.
Neoplasms (Cancer)
02/15/1988 - "
In vitro estrogenic actions in rat and human cells of hydroxylated derivatives of D16726 (zindoxifene), an agent with known antimammary cancer activity in vivo.
"
04/01/1985 - "
D 16726 was also active against MNU-induced rat mammary tumors and transplanted MXT tumors of the mouse.
"
07/01/1987 - "
Two antiestrogenic phenylindoles (D 16726 and D 15413) were tested for their prostatic tumor-inhibiting activity.
"
04/01/1985 - "
The inhibitory effect of 5-acetoxy-2-(4-acetoxyphenyl)-1-ethyl-3-methylindole (D 16726) on estrogen-dependent mammary tumors.
"
07/01/1987 - "
The tumor-inhibiting activity of D 16726 and D 15413 on the androgen-dependent R 3327 Dunning prostatic carcinoma and the human prostatic tumor PC 82 implanted in nude mice equals that of castration or of diethylstilbestrol.
"
Related Drugs and Biologics
1.
Estrogen Receptor Modulators (Antiestrogen)
2.
Antineoplastic Agents (Antineoplastics)
3.
zindoxifene
4.
Cytostatic Agents
5.
Hormones (Hormone)
6.
Estrogens (Estrogen)
7.
Estradiol (Delestrogen)
8.
Diethylstilbestrol (Stilbestrol)
9.
Cisplatin (Platino)
10.
Androgens
Related Therapies and Procedures
1.
Castration