HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

2-nitrobenzyl acetate

Also Known As:
o-NBA; ortho-nitrobenzyl acetate
Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1. Choi, Han-Gon: 1 article (09/2021)
2. Kim, Hanju: 1 article (09/2021)
3. Lee, Eun Seong: 1 article (09/2021)
4. Lee, Junyeong: 1 article (09/2021)
5. Lee, Woo Tak: 1 article (09/2021)
6. Nguyen, Nguyen Thi: 1 article (09/2021)
7. Oh, Kyung Taek: 1 article (09/2021)
8. Youn, Yu Seok: 1 article (09/2021)

Related Diseases

1. Neoplasms (Cancer)
09/01/2021 - "Consequently, we propose our o-NBA/HAase-HSA-NPs may be a prototype for development of future nanoparticle-based HA-ECM-depleting tumor-ablating agents."
09/01/2021 - "These results clearly demonstrated that when administered with paclitaxel NPs, our photoreactive o-NBA/HAase-HSA-NPs were able to reduce pH and degrade HA-based ECM, and thereby significantly suppress tumor growth. "
09/01/2021 - "Hyaluronidase (HAase) destroys hyaluronic acid-based tumor ECM, but it is active solely at acidic pHs of around 5.0 and is much less active at physiological pH. Herein, we report the development of our novel UV-light-reactive proton-generating and hyaluronidase-loaded albumin nanoparticles (o-NBA/HAase-HSA-NPs). "
09/01/2021 - "When in suspension/PEG-hydrogel and irradiated with UV light, the prepared o-NBA/HAase-HSA-NPs clearly reduced the pH of the surrounding medium to as low as 5.0 by producing protons and were better able to break down HA-based tumor cell spheroids (AsPC-1) and HA-hydrogel/microgels, presumably due to the enhanced HA activity at a more optimal pH. Moreover, when formulated as an intratumor-injectable PEG hydrogel, the o-NBA/HAase-HSA-NPs displayed significantly enhanced tumor suppression when combined with intravenous paclitaxel-loaded HSA-NPs (PTX-HSA-NPs) in AsPC-1 tumor-bearing mice: The tumor volume in mice administered UV-activated o-NBA/HAase-HSA-NPs and PTX-HSA-NPs was 198.2 ​± ​30.0 ​mm3, whereas those administered PBS or non-UV-activated o-NBA/HAase-HSA-NPs and PTX-HSA-NPs had tumor volumes of 1230.2 ​± ​256.2 and 295.4 ​± ​17.1 ​mm3, respectively. "

Related Drugs and Biologics

1. Hydrogels
2. Paclitaxel (Taxol)
3. Suspensions
4. Protons (Proton)
5. Hyaluronoglucosaminidase (Hyaluronidase)
6. Hyaluronic Acid (Hyaluronan)
7. Albumins
8. Microgels

Related Therapies and Procedures

1. Injections