apolipoprotein A-I Tangier

apolipoprotein A-I and isoforms found in patients with Tangier disease
Also Known As:
Tangier apo A-I; Tangier proapo A-I; apo A-I Tangier; apoA-I Tangier; pro-apo A-I Tangier; pro-apolipoprotein A-I Tangier; proapolipoprotein A-I Tangier
Networked: 4 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Related Diseases

1. Tangier Disease
10/15/1985 - "These results are interpreted as indicating that there is no major structural defect in Tangier apo-A-I, and the rapid rate of catabolism of apo-A-I in Tangier disease is due to a post-translational defect in apo-A-I metabolism."
10/01/1983 - "These results suggest that the underlying defect in Tangier disease may be a faulty conversion of pro-apo A-I to mature apo A-I, either due to a defect in the converting enzyme activity or to a further specific structural defect in Tangier apo A-I. The failure of Tangier pro-apo A-I to associate with HDL may be at least partially responsible for the HDL deficiency in Tangier subjects."
04/01/1982 - "Tangier disease: a structural defect in apolipoprotein A-I (apoA-I Tangier)."
11/01/1982 - "These data are consistent with the concept that apoA-I(Tangier) is functionally and metabolically distinct from normal apoA-I, and is the cause of the striking hypercatabolism of apoA-I and apoA-II, and the lipoprotein abnormalities observed in Tangier disease."
04/01/1982 - "These results have been interpreted as indicating that apoA-I Tangier has a different covalent structure than does normal apoA-I, and apoA-II Tangier is identical to normal apoA-II. This structural change in apoA-I Tangier is associated with rapid catabolism of apoA-I Tangier-and apoA-II Tangier-containing plasma lipoproteins, and it leads to the deficiency in high density lipoproteins, abnormal chylomicron remnants, and the intracellular accumulation of cholesterol ester characteristic of Tangier disease."

Related Drugs and Biologics

1. Apolipoprotein A-I (Apolipoprotein A1)
2. Apolipoprotein A-II (Apolipoprotein A2)
3. Lipoproteins (Lipoprotein)
4. Chylomicron Remnants
5. HDL Lipoproteins
6. Cholesterol