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tropomyosin kinase

from chick embryo; requires Mg; Ca & cyclic AMP not needed

Networked: 14 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Transferases: 6589
    - Phosphotransferases: 42769
      - Phosphotransferases (Alcohol Group Acceptor)
        Protein Kinases: 9677
        tropomyosin kinase: 14

Experts

1.	Adhikari, Bishnu: 1 article (01/2022)
2.	Arituluk, Zekiye Ceren: 1 article (01/2022)
3.	Ciesla, Lukasz M: 1 article (01/2022)
4.	Goodman, Caroline: 1 article (01/2022)
5.	Maitra, Urmila: 1 article (01/2022)
6.	Dong, Xin: 1 article (12/2021)
7.	Li, Cong: 1 article (12/2021)
8.	Li, Xiaodong: 1 article (12/2021)
9.	Liu, Junni: 1 article (12/2021)
10.	Sun, Yuanyuan: 1 article (12/2021)

Related Diseases

1.	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 01/01/2023 - "In patients with non-small cell lung cancer (NSCLC) harboring a fusion of the neurotrophic receptor kinase (NTRK) gene 1 or 3, treatment with tropomyosin kinase (TRK) inhibitors have shown promising results, however so far no data on efficacy of these agents in patients with NSCLC and NTRK2 fusion are available. "
2.	Ischemia 01/01/2009 - "Recent studies suggest the capacity of neurotrophins, via their tropomyosin-kinase receptors, to promote therapeutic neovascularization in animal models of hindlimb ischemia. "
3.	Ganglion Cysts (Ganglion) 12/01/2018 - "AION: anterior ischemic optic neuropathy, BDNF: Brain-derived neurotrophic factor, GCC: ganglion cell complex, MAP: mitogen-activated protein, OCT: spectral-domain optical coherence tomography, OD: right eye, ON: optic nerve, ONH: optic nerve head, OS: left eye, RGC: retinal ganglion cell; Trk: tropomyosin kinase." 08/05/1996 - "The large neuropeptide tyrosine (NPY)-expressing ganglion neurons (type I ganglion neurons) matured postnatally, with marked increases in acetylcholinesterase (AChE)-, neurofilament 10 (NF10)-, and tyrosine hydroxylase (TH)-like immunoreactivities (LIs) paralleled by increasing levels of mRNAs encoding NPY, low-affinity neurotrophin receptor (LANR), and tropomyosin kinase receptor (trk). "
4.	Neoplasms (Cancer) 12/01/2020 - "Larotrectinib is a first-generation tropomyosin kinase inhibitor, approved for the treatment of solid tumors. " 01/01/2019 - "Herein, a novel mechanism involving E2-dependent upregulation of brain-derived neurotrophic factor (BDNF) in astrocytes, and subsequent activation of tumor cell tropomyosin kinase receptor B (TrkB), is identified. "
5.	Chronic Pain 11/11/2021 - "In Pursuit of an Allosteric Human Tropomyosin Kinase A (hTrkA) Inhibitor for Chronic Pain."

Related Drugs and Biologics

1.	Phosphotransferases (Kinase)
2.	Nerve Growth Factors (Neurotrophins)
3.	Brain-Derived Neurotrophic Factor (BDNF)
4.	Nerve Growth Factor (NGF)
5.	Proteins (Proteins, Gene)
6.	Caspase 3 (Caspase-3)
7.	trkB Receptor
8.	Nerve Growth Factor Receptors (Neurotrophin Receptors)
9.	Tyrosine 3-Monooxygenase (Tyrosine Hydroxylase)
10.	Messenger RNA (mRNA)