N-methyl-D-glucamine dithiocarbamate

antidote for cadmium intoxication; repeated administration can result in reduction in cadmium levels of kidney & liver; structure given in first source
Also Known As:
D-N-methyl glucamine dithiocarbamate; Fe-MGD; N-MGDC; N-methyl-D-glucamine dithiocarbamate iron; N-methyl-N-dithiocarboxyglucamine; iron N-methyl glucamine dithiocarbamate; D-Glucitol, 1-deoxy-1-((dithiocarboxy)methylamino)-, monosodium salt
Networked: 10 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results


1. Dornon, Lucy: 1 article (01/2009)
2. Wu, Miaozong: 1 article (01/2009)
3. Rice, Kevin M: 1 article (01/2009)
4. Laurino, Joseph P: 1 article (01/2009)
5. Studeny, Mark: 1 article (01/2009)
6. Walker, Ernest M: 1 article (01/2009)
7. Morrison, Ryan G: 1 article (01/2009)
8. Wehner, Paulette S: 1 article (01/2009)
9. Walker, Sandra M: 1 article (01/2009)
10. Blough, Eric R: 1 article (01/2009)

Related Diseases

1. Ischemia
2. Cardiac Arrhythmias (Arrythmia)
3. Body Weight (Weight, Body)
03/01/1984 - "A single intraperitoneal injection of sodium N-methyl-D-glucamine dithiocarbamate (NaNMG-DTC), administered at a level greater than 1.1 mmol/kg body weight, protects against a normally lethal (greater than 95%) dose of cadmium chloride (10 mg CdCl2/kg body weight) and results in a subsequent dose-dependent decrease in the liver and kidney burdens of cadmium ion. "
05/01/1993 - "We have investigated the effect of an intraperitoneal cisplatin injection (5 mg/kg body weight) into male Wistar rats on: (1) body weight; (2) proximal tubular transport of D-glucose and sulfate across the luminal membrane; (3) transport of p-aminohippuric acid (PAH) and sulfate across the contraluminal membrane; (4) urinary excretion of inulin; (5) urinary excretion and tissue accumulation of sulfofluorescein, and (6) effect of the 'protecting substances', N-Methyl-D-glucamine-dithiocarbamate (NaG), diethyldithiocarbamate, mercaptosuccinate (MS), probenecid, and glycine on parameters 1, 4 and 5. Five days after intraperitoneal application of cisplatin the following effects were observed: (1) body weight was reduced on average by 11% as compared to a 12% increase in control animals; (2) luminal sulfate and D-glucose transport was inhibited correlating with the degree of weight loss; (3) contraluminal PAH transport was also decreased in correlation to the loss of body weight, while contraluminal sulfate transport was not inhibited by cisplatin; (4) inulin excretion was reduced by 45%, the pattern for protection was the same as for the prevention of weight loss; (5) sulfofluorescein (SF) excretion in the urine was reduced by 43%, and (6) accumulation of SF into cortical tissue was augmented. "
4. Weight Loss (Weight Reduction)
5. Tetanus

Related Drugs and Biologics

1. Iron
2. Deferoxamine (Desferal)
3. Acetaminophen (Paracetamol)
4. Sodium
5. Cisplatin (Platino)
6. Cadmium Chloride (Cadmium Dichloride)
7. Probenecid (Benemid)
8. Phenobarbital (Luminal)
9. p-Aminohippuric Acid (p-Aminohippurate)
10. Inulin

Related Therapies and Procedures

1. Intraperitoneal Injections