N-methyl-D-glucamine dithiocarbamate

antidote for cadmium intoxication; repeated administration can result in reduction in cadmium levels of kidney & liver; structure given in first source

Also Known As:

D-N-methyl glucamine dithiocarbamate; Fe-MGD; N-MGDC; N-methyl-D-glucamine dithiocarbamate iron; N-methyl-N-dithiocarboxyglucamine; iron N-methyl glucamine dithiocarbamate; D-Glucitol, 1-deoxy-1-((dithiocarboxy)methylamino)-, monosodium salt

Networked: 11 relevant articles (0 outcomes, 3 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Blough, Eric R: 1 article (01/2009)
2.	Dornon, Lucy: 1 article (01/2009)
3.	Laurino, Joseph P: 1 article (01/2009)
4.	Morrison, Ryan G: 1 article (01/2009)
5.	Rice, Kevin M: 1 article (01/2009)
6.	Studeny, Mark: 1 article (01/2009)
7.	Walker, Ernest M: 1 article (01/2009)
8.	Walker, Sandra M: 1 article (01/2009)
9.	Wehner, Paulette S: 1 article (01/2009)
10.	Wu, Miaozong: 1 article (01/2009)

Related Diseases

1.	Ischemia 01/06/1995 - "Therefore, electron paramagnetic resonance studies were performed to directly measure NO. in isolated rat hearts subjected to global ischemia, using the direct NO. trap Fe(2+)-N-methyl-D-glucamine dithiocarbamate, which specifically binds NO. giving rise to a characteristic triplet EPR spectrum with g = 2.04 and aN = 13.2 G. " 02/01/2001 - "Isolated rat hearts were subjected to control perfusion, or ischemia followed by reperfusion in the presence of Fe-MGD with electron paramagnetic resonance measurements performed on the effluent from these hearts. " 10/01/1997 - "The aqueous-soluble complex of Fe and N-methyl-D-glucamine dithiocarbamate (MGD) formed MGD2-Fe-NO complex with a characteristic triplet EPR signal (aN 12.5 G and giso = 2.04) at room temperature, in native isolated rat hearts following 40 min global ischemia and 15 min reperfusion. " 11/15/1996 - "Isolated rat hearts were subjected either to normal perfusion or to reperfusion after 30 min of ischemia in the presence of the NO. trap Fe2+-N-methyl-D-glucamine dithiocarbamate with electron paramagnetic resonance measurements performed on the effluent. " 08/01/1996 - "Rat hearts were loaded with 10 mM nitrite and subjected to global no-flow ischemia, during which time a series of three-dimensional spatial electron paramagnetic resonance (EPR) images of the distribution of NO were obtained using the NO trap bis(N-methyl-D-glucamine dithiocarbamate)iron(II). "
2.	Teratogenesis 09/01/1990 - "The present study evaluated the influence of sodium N-benzyl-D-glucamine dithiocarbamate, sodium N-di(hydroxyethyl)amine dithiocarbamate, sodium 4-carboxyamidopiperidine-N-dithiocarbamate, and sodium N-methyl-D-glucamine dithiocarbamate on Cd-induced teratogenesis in the hamster. "
3.	Cardiac Arrhythmias (Arrythmia) 01/01/2009 - "This study tested if acetaminophen, N-methyl-D-glucamine dithiocarbamate (NMGDTC), deferoxamine, and combinations of these agents reduce excess iron content, prevent iron-induced pathology, reduce cardiac arrhythmias, and reduce mortality in iron-overloaded gerbils. "
4.	Body Weight (Weight, Body) 03/01/1984 - "A single intraperitoneal injection of sodium N-methyl-D-glucamine dithiocarbamate (NaNMG-DTC), administered at a level greater than 1.1 mmol/kg body weight, protects against a normally lethal (greater than 95%) dose of cadmium chloride (10 mg CdCl2/kg body weight) and results in a subsequent dose-dependent decrease in the liver and kidney burdens of cadmium ion. " 05/01/1993 - "We have investigated the effect of an intraperitoneal cisplatin injection (5 mg/kg body weight) into male Wistar rats on: (1) body weight; (2) proximal tubular transport of D-glucose and sulfate across the luminal membrane; (3) transport of p-aminohippuric acid (PAH) and sulfate across the contraluminal membrane; (4) urinary excretion of inulin; (5) urinary excretion and tissue accumulation of sulfofluorescein, and (6) effect of the 'protecting substances', N-Methyl-D-glucamine-dithiocarbamate (NaG), diethyldithiocarbamate, mercaptosuccinate (MS), probenecid, and glycine on parameters 1, 4 and 5. Five days after intraperitoneal application of cisplatin the following effects were observed: (1) body weight was reduced on average by 11% as compared to a 12% increase in control animals; (2) luminal sulfate and D-glucose transport was inhibited correlating with the degree of weight loss; (3) contraluminal PAH transport was also decreased in correlation to the loss of body weight, while contraluminal sulfate transport was not inhibited by cisplatin; (4) inulin excretion was reduced by 45%, the pattern for protection was the same as for the prevention of weight loss; (5) sulfofluorescein (SF) excretion in the urine was reduced by 43%, and (6) accumulation of SF into cortical tissue was augmented. "
5.	Weight Loss (Weight Reduction) 05/01/1993 - "We have investigated the effect of an intraperitoneal cisplatin injection (5 mg/kg body weight) into male Wistar rats on: (1) body weight; (2) proximal tubular transport of D-glucose and sulfate across the luminal membrane; (3) transport of p-aminohippuric acid (PAH) and sulfate across the contraluminal membrane; (4) urinary excretion of inulin; (5) urinary excretion and tissue accumulation of sulfofluorescein, and (6) effect of the 'protecting substances', N-Methyl-D-glucamine-dithiocarbamate (NaG), diethyldithiocarbamate, mercaptosuccinate (MS), probenecid, and glycine on parameters 1, 4 and 5. Five days after intraperitoneal application of cisplatin the following effects were observed: (1) body weight was reduced on average by 11% as compared to a 12% increase in control animals; (2) luminal sulfate and D-glucose transport was inhibited correlating with the degree of weight loss; (3) contraluminal PAH transport was also decreased in correlation to the loss of body weight, while contraluminal sulfate transport was not inhibited by cisplatin; (4) inulin excretion was reduced by 45%, the pattern for protection was the same as for the prevention of weight loss; (5) sulfofluorescein (SF) excretion in the urine was reduced by 43%, and (6) accumulation of SF into cortical tissue was augmented. "

Related Drugs and Biologics

1.	Sodium
2.	Iron
3.	Deferoxamine (Desferal)
4.	Amines
5.	Acetaminophen (Paracetamol)
6.	Cisplatin (Platino)
7.	Cadmium Chloride (Cadmium Dichloride)
8.	Sulfates (Sulfates, Inorganic)
9.	Probenecid (Benemid)
10.	Phenobarbital (Luminal)

Related Therapies and Procedures

1.	Intraperitoneal Injections