|1.||Koeffler, H Phillip: 8 articles (06/2013 - 09/2008)|
|2.||Deng, Yihui: 7 articles (04/2012 - 05/2008)|
|3.||Zhang, Meixia: 7 articles (04/2012 - 05/2008)|
|4.||Patmasiriwat, Pimpicha: 6 articles (01/2015 - 01/2010)|
|5.||Duangmano, Suwit: 5 articles (01/2015 - 01/2010)|
|6.||Toh, Melvin: 5 articles (06/2013 - 07/2009)|
|7.||Yin, Dong: 5 articles (09/2010 - 09/2008)|
|8.||Sun, Chunyan: 5 articles (08/2010 - 05/2008)|
|9.||Suksamrarn, Apichart: 4 articles (01/2015 - 01/2010)|
|10.||Thoennissen, Nils H: 4 articles (06/2013 - 07/2009)|
06/01/2015 - "Cucurbitacin B Alters the Expression of Tumor-Related Genes by Epigenetic Modifications in NSCLC and Inhibits NNK-Induced Lung Tumorigenesis."
01/01/2015 - "The eight most active cucurbitacin components against cancer are cucurbitacin B, D, E, I, IIa, L glucoside, Q, and R. "
07/10/2014 - "Cucurbitacin B (CuB) is a naturally occurring compound that is found abundantly in cucumbers and other vegetables, and it is known to exert anti-cancer activities (primarily via apoptosis-induction) in several human cancers. "
01/15/2014 - "Cucurbitacin B also activated Akt, a mechanistic feature exhibited by established mTOR inhibitors in many tumor cells. "
01/15/2014 - "However, the mechanisms by which cucurbitacin B inhibits tumor growth are not fully understood. "
|2.||Squamous Cell Carcinoma (Epidermoid Carcinoma)
10/01/2008 - "To determine whether cucurbitacin B can inhibit the growth of laryngeal squamous cell carcinoma, in the present study we investigated the antitumor effect of cucurbitacin B on Hep-2 cells. "
10/01/2008 - "Inhibitory effects of cucurbitacin B on laryngeal squamous cell carcinoma."
09/01/2010 - "Cucurbitacin B inhibits growth, arrests the cell cycle, and potentiates antiproliferative efficacy of cisplatin in cutaneous squamous cell carcinoma cell lines."
09/01/2010 - "Cucurbitacin B, a small molecule inhibitor of the Stat3 signaling pathway, enhances the chemosensitivity of laryngeal squamous cell carcinoma cells to cisplatin."
07/15/2015 - "In vivo and in vitro antitumor studies, CUB-PLC-BER and the unmodified cucurbitacin B-phospholipid complex (CUB-PLC) presented stronger antitumor efficacy against human cholangiocarcinoma cells (QBC939 cells) than free cucurbitacin B (CUB), while phospholipids (PL) itself had no significant toxicity. "
07/15/2015 - "In present study, a novel phospholipid complex loaded cucurbitacin B modified with berberine hydrochloride (CUB-PLC-BER) was prepared by a simple solvent evaporation method with the aim of improving bile duct-targeted drug delivery and therapeutic efficacy for cholangiocarcinoma (CC). "
07/15/2015 - "Improve bile duct-targeted drug delivery and therapeutic efficacy for cholangiocarcinoma by cucurbitacin B loaded phospholipid complex modified with berberine hydrochloride."
|5.||Breast Neoplasms (Breast Cancer)
01/01/2012 - "In this study, we explored the novel molecular response of cucurbitacin B in human breast cancer cells, MCF-7 and MDA-MB-231. "
04/15/2014 - "Our results show that Cucurbitacin B (CuB), a triterpenoid steroidal compound inhibited the growth of various breast cancer cells with an IC50 ranging from 18-50nM after 48 and 72 h of treatment. "
04/15/2014 - "Inhibition of Integrin-HER2 signaling by Cucurbitacin B leads to in vitro and in vivo breast tumor growth suppression."
06/15/2013 - "Previously, we have shown antiproliferative activity of cucurbitacin B (CuB) in breast cancer, and we hypothesized that combining CuB with chemotherapeutic agents can augment their antitumor effect. "
01/01/2013 - "We suggest that survivin could be an important target of cucurbitacin B in BRCA1 defective breast cancer cells."
|6.||Deoxycholic Acid (Sodium Deoxycholate)
|7.||Proteins (Proteins, Gene)
|1.||Heterologous Transplantation (Xenotransplantation)
|2.||Drug Therapy (Chemotherapy)