|1.||Szczeklik, A: 3 articles (12/2002 - 02/2001)|
|2.||Nizankowska, E: 3 articles (12/2002 - 02/2001)|
|3.||Arm, Jonathan P: 2 articles (01/2014 - 01/2004)|
|4.||Sampson, A P: 2 articles (07/2006 - 05/2003)|
|5.||Sanak, M: 2 articles (12/2002 - 02/2001)|
|6.||González-Cobos, José C: 1 article (02/2015)|
|7.||Zhang, Xuexin: 1 article (02/2015)|
|8.||Trebak, Mohamed: 1 article (02/2015)|
|9.||Stolwijk, Judith A: 1 article (02/2015)|
|10.||Matrougui, Khalid: 1 article (02/2015)|
|1.||Asthma (Bronchial Asthma)
01/01/2014 - "LTC4 synthase polymorphism modifies efficacy of botanical seed oil combination in asthma."
01/01/2004 - "The pharmacogenomics of 5-lipoxgenase and LTC4 synthase in bronchial asthma will be discussed."
03/01/2002 - "The gene coding for LTC4 synthase exists in two common alleles, one of which appears to be associated with a severe, steroid-dependent type of asthma. "
10/11/1994 - "Leukotriene-C4 synthase (LTC4S; EC 220.127.116.11) catalyzes the committed step in the biosynthesis of the peptidoleukotrienes, which are important in the pathogenesis of asthma. "
12/01/2002 - "Improvement of asthma was observed mostly in patients with a low baseline and non-IL-5 inducible expression of LTC4 synthase (LTC4S) mRNA in eosinophils. "
11/01/1996 - "Expression of GST-II was significantly diminished in diet-restricted mice in all age groups and was associated with a marked decrease in liver tumor development. "
11/01/2012 - "It was found that drug resistance development in all three strains of tumor cells is associated with significant increase in hGSTP1 and hGSTA4 gene expression, whereas increased hGSTK1 gene expression was detected only in resistant K562/CDDP and MCF-7/CDDP cells."
12/01/2008 - "Furthermore, these mediators also stimulated an up-regulation of LTC4 synthase in cancer cells as well as non-transformed cells. "
11/01/1996 - "The major GST form of colon 26 tumor was identified as GST-II, the Pi class form, and a minor form as GST-III belonging to the Mu class. "
11/01/1996 - "As most spontaneous liver tumors were GST-II positive, it can be speculated that they developed from GST-II positive initiated hepatocytes. "
05/01/1995 - "MK-0591, an indirect inhibitor of 5-lipoxygenase activity, was co-administered to rats injected with nephrotoxic rabbit serum, followed by assessment of renal function, morphology and microsomal LTC4 synthase activity on day 7. A significant improvement in glomerular function was noted (p < 0.05), together with a 50% reduction in proteinuria (p < 0.01) in animals receiving MK-0591 (60 mg kg-1 day-1). "
11/01/1999 - "LTC4 synthase (LTC4S) protein is present in the perinuclear membranes of a limited number of hematopoietic cells involved in allergic inflammation, including mast cells, eosinophils, basophils, and macrophages. "
02/01/2012 - "hGSTA4 is down-regulated significantly within 1 wk of thermal burn injury in the muscle and fat tissues of patients from the large-scale collaborative Inflammation and the Host Response to Injury multicentered study. "
05/10/1996 - "Fluorescent in situ hybridization mapped LTC4 synthase to chromosomal location 5q35, which is in close proximity to the cluster of genes for cytokines and receptors involved in the regulation of cells central to allergic inflammation and implicated in bronchial asthma."
09/29/1995 - "Thus, developmentally segregated regulation of the prostanoid and cysteinyl leukotriene pathways in lineage-related committed mast cell progenitors reveals the pleiotropism of this effector cell of allergic inflammation, a cytokine/growth factor basis for preferential expression of pathways of eicosanoid biosynthesis, and the particular role of IL-3 in regulating the expression of the proteins of the 5-LO/LTC4 synthase pathway."
|5.||Pulmonary Fibrosis (Hamman Rich Syndrome)
|2.||Arachidonate 5-Lipoxygenase (5 Lipoxygenase)
|6.||Glutathione Transferase (Glutathione S-Transferase)
|10.||Tretinoin (Retinoic Acid)