|1.||Flatt, P R: 11 articles (02/2015 - 07/2007)|
|2.||Flatt, Peter R: 11 articles (02/2009 - 10/2003)|
|3.||Irwin, N: 10 articles (02/2015 - 07/2007)|
|4.||Irwin, Nigel: 9 articles (02/2009 - 08/2005)|
|5.||Gault, Victor A: 8 articles (02/2009 - 10/2003)|
|6.||Lacroix, A: 6 articles (07/2004 - 02/2000)|
|7.||Gault, V A: 5 articles (02/2015 - 07/2007)|
|8.||Seino, Yutaka: 5 articles (01/2012 - 07/2002)|
|9.||Green, Brian D: 5 articles (06/2007 - 08/2005)|
|10.||O'Harte, Finbarr P M: 5 articles (06/2007 - 10/2003)|
07/01/2008 - "Such effects open up the possibility of exploiting GIP receptor antagonism for the treatment of obesity and insulin resistance. "
12/01/2007 - "GIP receptor antagonism reverses obesity, insulin resistance, and associated metabolic disturbances induced in mice by prolonged consumption of high-fat diet."
07/01/2002 - "In contrast, mice lacking the GIP receptor (Gipr(-/-)) fed a high-fat diet were clearly protected from both the obesity and the insulin resistance. "
08/01/2007 - "Chemical gastric inhibitory polypeptide receptor antagonism protects against obesity, insulin resistance, glucose intolerance and associated disturbances in mice fed high-fat and cafeteria diets."
08/01/2011 - "The presence of functional gastric inhibitory polypeptide (GIP) receptors on adipocytes and knowledge that GIP plays a key role in fat deposition suggests a beneficial effect of GIP receptor antagonism in obesity and insulin resistance. "
01/01/2009 - "Gastric inhibitory polypeptide receptor: association analyses for obesity of several polymorphisms in large study groups."
08/01/2013 - "Comparison of the independent and combined metabolic effects of subchronic modulation of CCK and GIP receptor action in obesity-related diabetes."
09/01/2012 - "Both GIP receptor agonists and antagonists have been demonstrated to display therapeutic potential to treat diabetes and obesity. "
12/30/2011 - "The glucose-dependent insulinotropic polypeptide receptor (GIPr) has been implicated in high fat diet-induced obesity and is proposed as an anti-obesity target despite an uncertainty regarding the mechanism of action. "
05/01/2011 - "[Effects of GIP receptor antagonist for treatment of obesity]."
06/01/2009 - "These findings make it unlikely that GIP or GIP receptor agonists will be useful in treating the hyperglycemia of patients with type 2 diabetes."
11/03/2007 - "These findings support the proposal that GIP receptor down-regulation in rodent T2DM is secondary to chronic hyperglycemia and that normalization of glycemia can restore GIP sensitivity."
11/03/2007 - "Reversal of islet GIP receptor down-regulation and resistance to GIP by reducing hyperglycemia in the Zucker rat."
11/03/2007 - "ZDF rats with extreme hyperglycemia demonstrated greater islet GIP receptor mRNA down-regulation (94.3+/-3.8%) than ZF rats (48.8+/-22.8%). "
11/03/2007 - "GIP receptor mRNA levels in ZDF rats returned to 83.0+/-17.9% of lean following normalization of hyperglycemia by phlorizin treatment and pancreas perfusions demonstrated markedly improved GIP responsiveness. "
|4.||Adrenocortical Adenoma (Disease, Conn's)
01/01/1998 - "[Aberrant expression of the GIP (Gastric Inhibitory Polypeptide) receptor in an adrenal cortical adenoma responsible for a case of food-dependent Cushing's syndrome]."
09/01/1996 - "In situ hybridization studies using a GIP receptor probe showed an abundant expression of GIP receptor messenger ribonucleic acid in the adrenocortical adenoma. "
02/01/2001 - "Food-dependent androgen and cortisol secretion by a gastric inhibitory polypeptide-receptor expressive adrenocortical adenoma leading to hirsutism and subclinical Cushing's syndrome: in vivo and in vitro studies."
01/01/2014 - "The ectopic expression of the glucose-dependent insulinotropic polypeptide receptor (GIPR) in the human adrenal gland causes significant hypercortisolemia after ingestion of each meal and leads to Cushing's syndrome, implying that human GIPR activation is capable of robustly activating adrenal glucocorticoid secretion. "
07/01/2004 - "Analysis of the putative regulatory region of the gastric inhibitory polypeptide receptor gene in food-dependent Cushing's syndrome."
01/01/2003 - "The best characterized example to date is the aberrant expression of the gastric inhibitory polypeptide receptor that causes 'food-dependent hypercortisolism'. "
11/01/2002 - "Analysis of the putative promoter region of the GIP receptor gene (GIPR) in GIP-dependent Cushing's syndrome (CS)."
12/01/1998 - "Food-dependent Cushing's syndrome: characterization and functional role of gastric inhibitory polypeptide receptor in the adrenals of three patients."
|2.||Pro(3)- glucose-dependent insulinotropic polypeptide
|3.||Gastric Inhibitory Polypeptide (Glucose Dependent Insulinotropic Peptide)
|4.||Messenger RNA (mRNA)
|6.||Glucagon-Like Peptide 1 (GLP 1)
|9.||Complementary DNA (cDNA)
|10.||glucagon-like peptide receptor (receptor, glucagon-like peptide)
|3.||Heterologous Transplantation (Xenotransplantation)