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FCE 20700
Also Known As:
11-deoxy-13,14-didehydro-16(S)-methylprostaglandin E2 methyl ester; 11-deoxy-13,14-didehydro-16-methyl-PGE2 methyl ester; FCE-20700; Prost-5-en-13-yn-1-oic acid, 15-hydroxy-16-methyl-9-oxo-, methyl ester, (5Z,15S,16S)-
Networked:
3
relevant articles (
0
outcomes,
1
trials/studies)
Bio-Agent Context: Research Results
Lipids: 114793
Fatty Acids: 27405
Unsaturated Fatty Acids: 8236
Eicosanoids: 3262
Prostaglandins: 17100
Prostaglandins E: 2673
Dinoprostone: 10047
FCE 20700: 3
Biological Factors: 2472
Inflammation Mediators: 1113
Autacoids: 276
Eicosanoids: 3262
Prostaglandins: 17100
Prostaglandins E: 2673
Dinoprostone: 10047
FCE 20700: 3
Related Diseases
1.
Edema (Dropsy)
01/01/1983 - "
A study was made of the interaction between FCE 20700 (11-deoxy-13,14-didehydro-16(S)-methyl-PGE2 methylester) at a fixed dose of 250 mcg/kg and the ulcerogenic and antiinflammatory effect of indomethacin (I) on rat carrageenin paw edema.
"
2.
Ulcer
07/01/1984 - "
A new, chemically stable analogue of PGE2, 11-deoxy-13,14-didehydro-16(S)-methyl PGE2 methylester (FCE 20700) was studied for the prevention of different gastrointestinal ulcers and for the inhibition of basal gastric acid secretion in the rat.
"
07/01/1984 - "
FCE 20700 was more potent than PGE2 in the prevention of stress-induced gastric ulcers (ED50 = 262 and 787 mcg/kg) and indomethacin-induced intestinal ulcers (ED50 = 557 and 4569 mcg/kg), and showed the same potency as PGE2 in the prevention of ethanol (ED50 = 9.2 and 14.8 mcg/kg) and indomethacin-induced gastric ulcers (ED50 = 37.8 and 22.3 mcg/kg).
"
3.
Stomach Ulcer (Gastric Ulcer)
07/01/1984 - "
FCE 20700 was more potent than PGE2 in the prevention of stress-induced gastric ulcers (ED50 = 262 and 787 mcg/kg) and indomethacin-induced intestinal ulcers (ED50 = 557 and 4569 mcg/kg), and showed the same potency as PGE2 in the prevention of ethanol (ED50 = 9.2 and 14.8 mcg/kg) and indomethacin-induced gastric ulcers (ED50 = 37.8 and 22.3 mcg/kg).
"
4.
Gastric Fistula
01/01/1987 - "
Intravenous FCE 20700 produced a significant inhibition of total acid output (TAO) induced by pentagastrin or histamine in gastric fistula (GF) dogs.
"
Related Drugs and Biologics
1.
Indomethacin (Indometacin)
2.
Carrageenan
3.
Dinoprostone (PGE2)
4.
Troleandomycin (TAO)
5.
Pentagastrin (Peptavlon)
6.
Histamine (Histamine Dihydrochloride)
7.
Ethanol (Ethyl Alcohol)
8.
Acids