|1.||Paumen, Miriam León: 1 article (05/2008)|
|2.||Kraak, Michiel H S: 1 article (05/2008)|
|3.||Van Gestel, Cornelius A M: 1 article (05/2008)|
|4.||Admiraal, Wim: 1 article (05/2008)|
|5.||Ter Laak, Thomas L: 1 article (05/2008)|
|6.||Stol, Paul: 1 article (05/2008)|
|7.||Sharda, Natasha: 1 article (01/2007)|
|8.||Sood, Divya: 1 article (01/2007)|
|9.||Griffin, Carly: 1 article (01/2007)|
|10.||McNulty, James: 1 article (01/2007)|
01/01/1994 - "In this study, we have investigated the action of 6(5H)-phenanthridinone, an isoquinoline derivative and one of the most potent PARP inhibitors described so far, on RDM4 murine lymphoma cells in culture. "
09/01/2000 - "In contrast, 6(5H)-phenanthridinone failed to affect the doxorubicin toxicity in murine lymphoma cells, whereas it prevented the cytotoxicity of this drug in the human cell line. "
12/01/1997 - "Effect of 6(5H)-phenanthridinone, a poly (ADP-ribose)polymerase inhibitor, and ionizing radiation on the growth of cultured lymphoma cells."
09/01/2000 - "Here, we evaluated the ability of the PARP inhibitor, 6(5H)-phenanthridinone, to modulate the antiproliferative activity of bleomycin, carmustin and doxorubicin in a murine (RDM4) and a human (U937) lymphoma cell lines. "
|2.||Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental)
01/01/2004 - "Hepatoprotective effects of 6(5H)-phenanthridinone from chemical-induced centrilobular necrosis."
11/01/2002 - "Both 6(5H)-phenanthridinone and benzamide attenuated development of EAE, reducing clinical score, neuroimmune infiltration and expression of inflammatory mediators such as inducible nitric oxide synthase, interleukin-1beta and -2, cyclooxygenase-2, tumour necrosis factor-alpha and interferon-gamma in the spinal cord of myelin-immunized rats. "
11/01/2002 - "In cultures of activated rat lymphocytes, 6(5H)-phenanthridinone and benzamide reduced the DNA-binding activity of NF-kappaB and AP-1 and transcription of pro-inflammatory cytokines such as interleukin-2, interferon-gamma and tumour necrosis factor-alpha. "
05/01/2008 - "The transformation product phenanthridone was not toxic at the tested concentrations (up to 4000 micromol/kg dry sediment), whereas EC50 values for the parent compound phenanthridine and the isomer acridone were below the estimated limit for narcosis, suggesting a specific mode of action. "
01/01/2007 - "Our results indicate that the phenanthridone skeleton in natural Amaryllidaceae alkaloids may be a significant common element for selectivity against cancer cells; furthermore, the configuration of the methoxy-side groups is responsible for higher binding affinity to the target protein/s thus making for a more efficient anti-cancer agent."
|2.||Benzoic Acid (Ucephan)
|4.||Interleukin-1beta (Interleukin 1 beta)
|5.||Nitric Oxide Synthase Type II (Inducible Nitric Oxide Synthase)
|6.||Cyclooxygenase 2 (Cyclooxygenase-2)
|8.||Transcription Factor AP-1 (Transcription Factor AP 1)
|10.||NF-kappa B (NF-kB)