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trimethyltin chloride

induces atrophy of thymus, spleen & lymph nodes but causes no change in bone marrow

Also Known As:

trimethyltin chloride, (117)Sn-labeled

Networked: 37 relevant articles (1 outcomes, 6 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Organometallic Compounds: 64
  - Organotin Compounds: 41
    - Trialkyltin Compounds: 1
      - Trimethyltin Compounds
        trimethyltin chloride: 37

Experts

1.	Ouyang, G L: 3 articles (04/2022 - 02/2019)
2.	Zhu, H B: 3 articles (04/2022 - 02/2019)
3.	Huang, Ming: 2 articles (01/2020 - 04/2010)
4.	Lai, Y Y: 2 articles (05/2019 - 02/2019)
5.	Zhong, S Q: 2 articles (05/2019 - 02/2019)
6.	Shi, Nian: 2 articles (01/2016 - 07/2013)
7.	Lai, Guanchao: 2 articles (05/2015 - 04/2010)
8.	Ruan, Xiaolin: 2 articles (05/2015 - 04/2010)
9.	Sui, Gang: 2 articles (05/2015 - 04/2010)
10.	Tang, Xiaojiang: 2 articles (05/2015 - 04/2010)

Related Diseases

1.	Cardiotoxicity 03/01/2022 - "Melatonin ameliorates trimethyltin chloride-induced cardiotoxicity: The role of nuclear xenobiotic metabolism and Keap1-Nrf2/ARE axis-mediated pyroptosis."
2.	Body Weight (Weight, Body) 01/01/1997 - "The present study was aimed to assess the comparative restoration of behavioural and neurochemical deficits in trimethyltin chloride (7.5 mg/Kg body weight, i.p) treated rats following single or multiple site fetal hippocampal transplants. " 09/01/1989 - "Pregnant rats were injected on gestational day 12 with single dose of trimethyltin chloride (TMT) ip at either 0, 5, or 7 mg/kg. Significant differences between treated and control offspring rats could not be observed in terms of body weight, pinna detachment, incisor eruption, eye opening, surface righting, cliff avoidance, pivoting, negative geotaxis and auditory startle. " 06/15/1985 - "Diurnal patterns of feeding, drinking, locomotor activity, and rearing in male Fischer-344 rats were examined for 2 weeks after a single oral dose of trimethyltin chloride (TMT) at 0, 3, 5, or 7 mg/kg. Body weights and feeding and drinking efficiency ratios (ratios of amount of food or water consumed per unit effort) were also determined daily. " 03/01/1982 - "BALB/c mice were injected IP with a single dose of trimethyltin chloride (3.0 mg TMT/kg body weight). "
3.	Hypokalemia 03/01/2002 - "Studies on hypokalemia induced by trimethyltin chloride." 04/30/2010 - "Mechanism underlying hypokalemia induced by trimethyltin chloride: Inhibition of H+/K+-ATPase in renal intercalated cells." 03/01/2002 - "To determine the possible relationship between plasma potassium concentration and severity of acute trimethyltin chloride (TMT) poisoning and to assess the mechanism of TMT induced hypokalemia. "
4.	Neoplasms (Cancer) 05/17/2018 - "This study was conducted to assess the antioxidant capacity and protective effect of the ethyl acetate fraction from persimmon (Diospyros kaki) (EFDK) on H₂O₂-induced hippocampal HT22 cells and trimethyltin chloride (TMT)-induced Institute of Cancer Research (ICR) mice. "
5.	Hepatocellular Carcinoma (Hepatoma) 09/01/2009 - "In evaluating the cytotoxic effects and the mechanisms of the apoptotic and necrotic actions of trimethyltin chloride (TMT) on human hepatoma G2 (HepG2) cells, the present study focused on the involvement of antiproliferation, DNA damage, cell death, apoptosis-related proteins, and p53-dependent transcriptional activity. "

Related Drugs and Biologics

1.	Melatonin
2.	Xenobiotics
3.	Antioxidants
4.	Proteins (Proteins, Gene)
5.	Ascorbic Acid (Vitamin C)
6.	Atomoxetine Hydrochloride (Strattera)
7.	ethyl acetate
8.	Adenosine Triphosphatases (ATPase)
9.	Potassium
10.	Plastics

Related Therapies and Procedures

1.	Lasers (Laser)
2.	Emergency Treatment