Gly thyrotropin-releasing hormone

substrate for enzymatic conversion to TRH; RN given refers to all (L)-isomer

Also Known As:

thyrotropin-releasing hormone, Gly; Gly-thyrotropin-releasing hormone; TRH, Gly; TRH-Gly; pGlu-His-Pro-Gly; pGlu-His-Pro-GlyOH; pyroglutamyl-histidyl-prolyl-glycine; thyrotropin-releasing hormone, glycine

Networked: 12 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Related Diseases

1.	Hypothyroidism 07/01/1989 - "Untreated hypothyroidism and exogenous TRH significantly increased adrenal TRH-Gly-IR levels. " 08/01/1989 - "Because testosterone levels do not change during the first 18 months of life in most rat strains, and hypothyroidism in young animals is associated with a significant increase in prostate TRH and TRH-Gly levels, we conclude that the aging-related decline in prostate TRH biosynthesis is not the result of a hypogonadal state." 01/01/1989 - "The ratio of TRH-Gly to TRH was significantly increased in the anterior pituitary by hypothyroidism and TRH injection, suggesting that thyroid hormones and TRH regulate the alpha-amidation of TRH-Gly to form TRH in this tissue. " 08/01/1987 - "Hypothyroidism induced by PTU significantly increased TRH-IR and TRH-Gly-IR levels in prostate and testis and reduced these levels in epididymis but did not affect the serum concentrations of testosterone compared with those of controls. "
2.	Seizures (Absence Seizure) 10/31/1994 - "Predominance of pGlu-His-Pro-Gly among all TRH precursor peptides in rat limbic forebrain after electroconvulsive seizures." 10/31/1994 - "1. After a series of electroconvulsive seizures, levels of TRH-Gly (the immediate precursor of TRH) in four limbic regions correlate significantly and highly with increased swimming in the forced-swim test model of antidepressant efficacy. "
3.	Acromegaly 01/01/1991 - "The present data suggest that TRH-Gly may participate in regulating GH secretion in some patients with acromegaly and that TRH-Gly-induced GH secretion may be due at least in part to TRH-associated mechanisms underlying GH secretion." 01/01/1991 - "TRH-Gly, a precursor of TRH, alters GH secretion in acromegaly." 07/01/1990 - "TRH-Gly did not alter PRL levels in patients with uremia, acromegaly, or prolactinoma. " 07/01/1990 - "The quantitative response of TRH-Gly-stimulated PRL, TSH, and GH was evaluated in nine patients with anorexia nervosa, six age-matched normal women, eight patients with uremia, five patients with acromegaly, and two patients with prolactinoma. " 01/01/1991 - "We explored effects of a precursor of thyrotropin (TSH)-releasing hormone (TRH), TRH-Gly, on growth hormone (GH) secretion in acromegaly. "
4.	Prolactinoma (Prolactinomas) 07/01/1990 - "TRH-Gly did not alter PRL levels in patients with uremia, acromegaly, or prolactinoma. " 07/01/1990 - "The quantitative response of TRH-Gly-stimulated PRL, TSH, and GH was evaluated in nine patients with anorexia nervosa, six age-matched normal women, eight patients with uremia, five patients with acromegaly, and two patients with prolactinoma. "
5.	Uremia 07/01/1990 - "TRH-Gly did not alter PRL levels in patients with uremia, acromegaly, or prolactinoma. " 07/01/1990 - "The quantitative response of TRH-Gly-stimulated PRL, TSH, and GH was evaluated in nine patients with anorexia nervosa, six age-matched normal women, eight patients with uremia, five patients with acromegaly, and two patients with prolactinoma. "

Related Drugs and Biologics

1.	Gly thyrotropin-releasing hormone
2.	Thyrotropin-Releasing Hormone (Protirelin)
3.	Urethane (Ethyl Carbamate)
4.	Thyrotropin (Thyroid-Stimulating Hormone)
5.	Testosterone (Sustanon)
6.	Prolactin
7.	Peptides (Polypeptides)
8.	Thyroid Hormones
9.	Growth Hormone (Somatotropin)
10.	Hormones (Hormone)

Related Therapies and Procedures

1.	Intravenous Injections