HOME PRODUCTS COMPANY CONTACT FAQ

Research Dictionary Pharma

Sign Up FREE or Login

omeprazole sulfone

omeprazole metabolite; structure given in first source

Also Known As:

omeprazole sulphone

Networked: 4 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Sulfur Compounds: 278
  - Sulfoxides: 23
    - 2-Pyridinylmethylsulfinylbenzimidazoles
      - Omeprazole: 3417
        omeprazole sulfone: 4
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyridines: 88
    - 2-Pyridinylmethylsulfinylbenzimidazoles
      - Omeprazole: 3417
        omeprazole sulfone: 4
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzimidazoles: 245
      - 2-Pyridinylmethylsulfinylbenzimidazoles
        Omeprazole: 3417
        omeprazole sulfone: 4

Experts

1.	Aboagye, Eric O: 1 article (01/2019)
2.	Clarke, Stephen: 1 article (01/2019)
3.	Edwards, Robert J: 1 article (01/2019)
4.	Lee, Patrizia: 1 article (01/2019)
5.	Liddle, Christopher: 1 article (01/2019)
6.	Lozan-Kuehne, Jingky P: 1 article (01/2019)
7.	Maslen, Lynn: 1 article (01/2019)
8.	Ramaswami, Ramya: 1 article (01/2019)
9.	Sharma, Rohini: 1 article (01/2019)
10.	Trousil, Sebastian: 1 article (01/2019)

Related Diseases

1.	Gastroesophageal Reflux (GERD) 07/01/2006 - "In an accompanying pharmacokinetic trial in 10 patients with GERD, both esomeprazole and 5-OH-esomeprazole (formed by CYP2C19) plasma levels and those of omeprazole-sulfone (formed by CYP3A4) were determined. " 12/01/2005 - "In a second trial plasma levels of esomeprazole and corresponding CYP2C19 and CYP3A4 metabolites (5-hydroxyomeprazole and omeprazole sulfone) were monitored in 10 CYP2C19 wild-type patients with GERD after the first and last doses (day 7) of 40 mg esomeprazole daily to calculate metabolic ratios. "
2.	Neoplasms (Cancer) 01/01/2019 - "CYP2E1 activity was markedly up-regulated in cancer (6-hydroxychlorzoxazone/chlorzoxazone ratio of 1.30 vs. 2.75), while CYP3A phenotypic activity was repressed in cancer (omeprazole sulfone/omeprazole ratio of 0.23 vs. 0.49). "
3.	Epilepsy (Aura) 08/01/2006 - "Plasma levels of omeprazole and omeprazole sulfone were analyzed by reversed-phase high-performance liquid chromatography in a blood sample drawn 3 h after intake of a single oral 20-mg dose of omeprazole by 22 healthy subjects and five patients with newly diagnosed epilepsy. "

Related Drugs and Biologics

1.	Cytochrome P-450 CYP3A
2.	Cytochrome P-450 CYP2C19
3.	Esomeprazole (Nexium)
4.	5-hydroxymethylomeprazole
5.	Omeprazole (Prilosec)
6.	Cytochrome P-450 CYP2E1 (CYP2E1)
7.	Chlorzoxazone